Loss of Metabolic Oscillations in a Multicellular Computational Islet of the Pancreas

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dc.contributor.authorPan, Jane
dc.contributor.authorGearhart, Gemma
dc.contributor.authorJiang, Shuai
dc.contributor.authorMay, Thomas J.
dc.date.accessioned2025-12-15T14:58:58Z
dc.date.issued2014
dc.description.abstractDiabetes mellitus, commonly known as diabetes, is a group of diseases in which the body either does not have the capability to produce insulin or is not capable of producing sufficient amounts of insulin to compensate for the glucose that enters the body. According to the American Diabetes Association (ADA), diabetes affects the lives of approximately 8.3 percent of the U.S. population of all ages and racial backgrounds [4]. People experience diabetes across all regions of the world.
dc.description.sponsorshipThese results were obtained as part of the REU Site: Interdisciplinary Program in High Performance Computing (www.umbc. edu/hpcreu) in the Department of Mathematics and Statistics at the University of Maryland, Baltimore County (UMBC) in Summer 2013, where they were originally reported in the tech. rep. [6]. This program is funded jointly by the National Science Foundation and the National Security Agency (NSF grant no. DMS–1156976), with additional support from UMBC, the Department of Mathematics and Statistics, the Center for Interdisciplinary Research and Consulting (CIRC), and the UMBC High Performance Computing Facility (HPCF). HPCF (www. umbc.edu/hpcf) is supported by the National Science Foundation through the MRI program (grant nos. CNS–0821258 and CNS–1228778) and the SCREMS program (grant no. DMS– 0821311), with additional substantial support from UMBC. Coauthor Jane Pan was supported, in part, by the UMBC National Security Agency (NSA) Scholars Program though a contract 52UMBC REVIEW 2014 with the NSA. We thank graduate RA Samuel Khuvis and faculty mentor Matthias K. Gobbert for their support with the simulations, and clients Bradford E. Peercy from UMBC and Arthur Sherman from the Laboratory of Biological Modeling at the National Institutes of Health for posing the physiological question and providing invaluable guidance.
dc.description.urihttps://ur.umbc.edu/wp-content/uploads/sites/354/2015/11/umbcReview2014.pdf#page=32
dc.format.extent23 pages
dc.genrejournal articles
dc.identifierdoi:10.13016/m2bjve-jvr1
dc.identifier.citationPan, Jane. “Loss of Metabolic Oscillations in a Multicellular Computational Islet of the Pancreas.” UMBC Review: Journal of Undergraduate Research 15 (2014): 32–53. https://ur.umbc.edu/wp-content/uploads/sites/354/2015/11/umbcReview2014.pdf#page=32
dc.identifier.urihttp://hdl.handle.net/11603/41291
dc.language.isoen
dc.publisherUniversity of Maryland, Baltimore County
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Mathematics and Statistics Department
dc.relation.ispartofUMBC Student Collection
dc.relation.ispartofUMBC Review
dc.relation.ispartofUMBC Meyerhoff Scholars Program
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.titleLoss of Metabolic Oscillations in a Multicellular Computational Islet of the Pancreas
dc.typeText

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