TO COMPARE AND CONTRAST EllF4E FOUND IN NUCLEOCYTOPLASMIC LARGE DNA VIRUSES SUCH AS THE MIIMIVIRUS AND THE PANDORAVIRUS WITH MAMMALIAN EN4E-1, EIIF4E-2 AND EllF4E-3 IN ORDER TO DISCOVER THE PURPOSE AND FUNCTION OF EIF4E IN THESE LARGE VIRUSES
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Date
2017-05
Type of Work
Department
Hood College Biology
Program
Biomedical and Environmental Science
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Abstract
The aim is to discover the purpose and function of eIF4E found in nucleocytoplasmic large DNA
viruses, but more specifically in the Mimivirus and the Pandoravirus. Initially, phylogenetic analysis will be
used to compare and contrast the eIF4E sequences discovered in the viruses to the sequences of the mammalian
eIF4E family members (eIF4E-1, eIF4E-2 & eIF4E-3). I will look for key sites, similarities and differences in
the sequences of the viral eIF4Es. This analysis will provide some insight to the possible outcomes of the
following laboratory eIF4E experiments.