Epidemiology of Sepsis in US Children and Young Adults

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dc.contributor.authorMagill, Shelley S
dc.contributor.authorSapiano, Mathew R P
dc.contributor.authorGokhale, Runa
dc.contributor.authorNadle, Joelle
dc.contributor.authorWilson, Lucy E
dc.contributor.authorPerlmutter, Rebecca
dc.contributor.authoret al
dc.date.accessioned2023-05-22T15:46:57Z
dc.date.available2023-05-22T15:46:57Z
dc.date.issued2023-04-20
dc.descriptionAuthors: - Shelley S Magill, Mathew R P Sapiano, Runa Gokhale, Joelle Nadle, Helen Johnston, Geoff Brousseau, Meghan Maloney, Susan M Ray, Lucy E Wilson, Rebecca Perlmutter, Ruth Lynfield, Malini DeSilva, Marla Sievers, Lourdes Irizarry, Ghinwa Dumyati, Rebecca Pierce, Alexia Zhang, Marion Kainer, Anthony E Fiore, Raymund Dantes, Lauren Epsteinen_US
dc.description.abstractBackground Most multicenter studies of US pediatric sepsis epidemiology use administrative data or focus on pediatric intensive care units. We conducted a detailed medical record review to describe sepsis epidemiology in children and young adults. Methods In a convenience sample of hospitals in 10 states, patients aged 30 days–21 years, discharged during 1 October 2014–30 September 2015, with explicit diagnosis codes for severe sepsis or septic shock, were included. Medical records were reviewed for patients with documentation of sepsis, septic shock, or similar terms. We analyzed overall and age group–specific patient characteristics. Results Of 736 patients in 26 hospitals, 442 (60.1%) had underlying conditions. Most patients (613 [83.3%]) had community-onset sepsis, although most community-onset sepsis was healthcare associated (344 [56.1%]). Two hundred forty-one patients (32.7%) had outpatient visits 1–7 days before sepsis hospitalization, of whom 125 (51.9%) received antimicrobials ≤30 days before sepsis hospitalization. Age group–related differences included common underlying conditions (<5 years: prematurity vs 5–12 years: chronic pulmonary disease vs 13–21 years: chronic immunocompromise); medical device presence ≤30 days before sepsis hospitalization (1–4 years: 46.9% vs 30 days–11 months: 23.3%); percentage with hospital-onset sepsis (<5 years: 19.6% vs ≥5 years: 12.0%); and percentage with sepsis-associated pathogens (30 days–11 months: 65.6% vs 13–21 years: 49.3%). Conclusions Our data suggest potential opportunities to raise sepsis awareness among outpatient providers to facilitate prevention, early recognition, and intervention in some patients. Consideration of age-specific differences may be important as approaches are developed to improve sepsis prevention, risk prediction, recognition, and management.en_US
dc.description.sponsorshipThis work was supported by the Centers for Disease Control and Prevention through the Emerging Infections Program cooperative agreement CK12-1202 and CK17-1701.en_US
dc.description.urihttps://academic.oup.com/ofid/article/10/5/ofad218/7132336en_US
dc.format.extent10 pagesen_US
dc.genrejournal articlesen_US
dc.genrepostprintsen_US
dc.identifierdoi:10.13016/m2uksh-j3qo
dc.identifier.citationMagill, Shelley S, et al. "Epidemiology of Sepsis in U.S. Children and Young Adults" Open Forum Infectious Diseases, ofad218 (20 April, 2023). https://doi.org/10.1093/ofid/ofad218.en_US
dc.identifier.urihttps://doi.org/10.1093/ofid/ofad218
dc.identifier.urihttp://hdl.handle.net/11603/28028
dc.language.isoen_USen_US
dc.publisherOxford University Pressen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Emergency Health Services Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.relation.ispartofUMBC School of Public Policy
dc.relation.ispartofA. All Hilltop Institute (UMBC) Works
dc.rightsThis work was written as part of one of the author's official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.en_US
dc.rightsPublic Domain Mark 1.0*
dc.rights.urihttp://creativecommons.org/publicdomain/mark/1.0/*
dc.titleEpidemiology of Sepsis in US Children and Young Adultsen_US
dc.typeTexten_US

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