Relations Among Anhedonia, Reinforcement Learning, and Global Functioning in Help-seeking Youth

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dc.contributor.authorAkouri-Shan, LeeAnn
dc.contributor.authorSchiffman, Jason
dc.contributor.authorMillman, Zachary B
dc.contributor.authorDemro, Caroline
dc.contributor.authorFitzgerald, John
dc.contributor.authorRouhakhtar, Pamela Rakhshan
dc.contributor.authorRedman, Samantha
dc.contributor.authorReeves, Gloria M
dc.contributor.authorChen, Shuo
dc.contributor.authorGold, James M
dc.contributor.authorMartin, Elizabeth A
dc.contributor.authorCorcoran, Cheryl
dc.contributor.authorRoiser, Jonathan P
dc.contributor.authorBuchanan, Robert W
dc.contributor.authorRowland, Laura M
dc.contributor.authorWaltz, James A
dc.date.accessioned2023-08-23T22:12:08Z
dc.date.available2023-08-23T22:12:08Z
dc.date.issued2021-07-08
dc.description.abstractDysfunction in the neural circuits underlying salience signaling is implicated in symptoms of psychosis and may predict conversion to a psychotic disorder in youth at clinical high risk (CHR) for psychosis. Additionally, negative symptom severity, including consummatory and anticipatory aspects of anhedonia, may predict functional outcome in individuals with schizophrenia-spectrum disorders. However, it is unclear whether anhedonia is related to the ability to attribute incentive salience to stimuli (through reinforcement learning [RL]) and whether measures of anhedonia and RL predict functional outcome in a younger, help-seeking population. We administered the Salience Attribution Test (SAT) to 33 participants who met criteria for either CHR or a recent-onset psychotic disorder and 29 help-seeking youth with nonpsychotic disorders. In the SAT, participants must identify relevant and irrelevant stimulus dimensions and be sensitive to different reinforcement probabilities for the 2 levels of the relevant dimension (“adaptive salience”). Adaptive salience attribution was positively related to both consummatory pleasure and functioning in the full sample. Analyses also revealed an indirect effect of adaptive salience on the relation between consummatory pleasure and both role (αβ = .22, 95% CI = 0.02, 0.48) and social functioning (αβ = .14, 95% CI = 0.02, 0.30). These findings suggest a distinct pathway to poor global functioning in help-seeking youth, via impaired reward sensitivity and RL.en_US
dc.description.sponsorshipThis research was made possible by Grant # R01MH112612 from the National Institute of Mental Health (JS, JF, PJRR, SR, GMR), Grant # R01MH107558 from the National Institute of Mental Health (CC), Grant # P50MH115846 from the National Institute of Mental Health (ZM), funding from the James J Peters VA MIRECC (CC), and a contract from the Maryland Department of Health and Mental Hygiene, Behavioral Health Administration through the Maryland Center of Excellence on Early Intervention Program (MEIP; OPASS# 14-13717G/M00B4400241; JS, JF, PJRR, SR, GMR, RWB).en_US
dc.description.urihttps://academic.oup.com/schizophreniabulletin/article/47/6/1534/6317598en_US
dc.format.extent10 pagesen_US
dc.genrejournal articlesen_US
dc.genrepostprintsen_US
dc.identifierdoi:10.13016/m2sxay-i5x3
dc.identifier.citationLeeAnn Akouri-Shan and others, Relations Among Anhedonia, Reinforcement Learning, and Global Functioning in Help-seeking Youth, Schizophrenia Bulletin, Volume 47, Issue 6, November 2021, Pages 1534–1543, https://doi.org/10.1093/schbul/sbab075en_US
dc.identifier.urihttps://doi.org/10.1093/schbul/sbab075
dc.identifier.urihttp://hdl.handle.net/11603/29328
dc.language.isoen_USen_US
dc.publisherOxford University Pressen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Psychology Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.relation.ispartofUMBC Student Collection
dc.rightsThis is a pre-copyedited, author-produced version of an article accepted for publication in Schizophrenia Bulletin following peer review. The version of record LeeAnn Akouri-Shan and others, Relations Among Anhedonia, Reinforcement Learning, and Global Functioning in Help-seeking Youth, Schizophrenia Bulletin, Volume 47, Issue 6, November 2021, Pages 1534–1543, https://doi.org/10.1093/schbul/sbab075 is available online at:https://doi.org/10.1093/schbul/sbab075.en_US
dc.titleRelations Among Anhedonia, Reinforcement Learning, and Global Functioning in Help-seeking Youthen_US
dc.typeTexten_US
dcterms.creatorhttps://orcid.org/0000-0002-1363-4497en_US
dcterms.creatorhttps://orcid.org/0000-0001-8008-3552en_US
dcterms.creatorhttps://orcid.org/0000-0003-1291-6422en_US

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