Carbocyclic pyrimidine nucleosides as inhibitors of S-adenosylhomocysteine hydrolase
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Mosley, Sylvester L., Brian A. Bakke, Joshua M. Sadler, Naresh K. Sunkara, Kathleen M. Dorgan, Zhaohui Sunny Zhou, and Katherine L. Seley-Radtke. “Carbocyclic Pyrimidine Nucleosides as Inhibitors of S-Adenosylhomocysteine Hydrolase.” Bioorganic & Medicinal Chemistry 14, no. 23 (December 1, 2006): 7967–71. https://doi.org/10.1016/j.bmc.2006.07.052.
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Abstract
The design, synthesis, and unexpected inhibitory activity against S-adenosyl-homocysteine (SAH) hydrolase (SAHase, EC 3.3.1.1) for a series of truncated carbocyclic pyrimidine nucleoside analogues is presented. Of the four nucleosides obtained, 10 was found to be active with a Ki value of 5.0μM against SAHase.