Carbocyclic pyrimidine nucleosides as inhibitors of S-adenosylhomocysteine hydrolase

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dc.contributor.authorMosley, Sylvester L.
dc.contributor.authorBakke, Brian A.
dc.contributor.authorSadler, Joshua M.
dc.contributor.authorSunkara, Naresh Kumar
dc.contributor.authorDorgan, Kathleen M.
dc.contributor.authorZhou, Zhaohui Sunny
dc.contributor.authorSeley-Radtke, Katherine
dc.date.accessioned2025-07-30T19:22:51Z
dc.date.issued2006-08-10
dc.description.abstractThe design, synthesis, and unexpected inhibitory activity against S-adenosyl-homocysteine (SAH) hydrolase (SAHase, EC 3.3.1.1) for a series of truncated carbocyclic pyrimidine nucleoside analogues is presented. Of the four nucleosides obtained, 10 was found to be active with a Ki value of 5.0μM against SAHase.
dc.description.sponsorshipThis work was supported by the National Cancer Institute (NCI/NIH RO1 CA 97634 to KSR), the National Institute of Allergy and Infectious Diseases (NIAID/NIH, 1R01AI058146 to ZSZ.), the National Institutes of Health/NIGMS Initiative for Minority Student Development (R25-GM55036 to SLM), and the Herman Frasch Foundation (541-HF02 to ZSZ). We are grateful to Prof. George Carmen of Rutgers University for the CTP synthetase assay and Prof. Moshe Szyf of McGill University for the DNA methyltransferase assays.
dc.description.urihttps://www.sciencedirect.com/science/article/pii/S0968089606006067
dc.format.extent13 pages
dc.genrejournal articles
dc.genrepostprints
dc.identifierdoi:10.13016/m2rlng-kwk3
dc.identifier.citationMosley, Sylvester L., Brian A. Bakke, Joshua M. Sadler, Naresh K. Sunkara, Kathleen M. Dorgan, Zhaohui Sunny Zhou, and Katherine L. Seley-Radtke. “Carbocyclic Pyrimidine Nucleosides as Inhibitors of S-Adenosylhomocysteine Hydrolase.” Bioorganic & Medicinal Chemistry 14, no. 23 (December 1, 2006): 7967–71. https://doi.org/10.1016/j.bmc.2006.07.052.
dc.identifier.urihttps://doi.org/10.1016/j.bmc.2006.07.052
dc.identifier.urihttp://hdl.handle.net/11603/39608
dc.language.isoen_US
dc.publisherElsevier
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Faculty Collection
dc.relation.ispartofUMBC Chemistry & Biochemistry Department
dc.relation.ispartofUMBC Student Collection
dc.rightsCreative Commons Attribution Non-Commercial No Derivatives
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.en
dc.subjectMTAN
dc.subjectCarbocyclic
dc.subjectPyrimidine
dc.subjectSAHase
dc.subjectNucleoside
dc.titleCarbocyclic pyrimidine nucleosides as inhibitors of S-adenosylhomocysteine hydrolase
dc.typeText
dcterms.creatorhttps://orcid.org/0000-0002-0154-3459

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