Lifetime Discrimination Burden, Racial Discrimination, and Subclinical Cerebrovascular Disease among African Americans

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dc.contributor.authorMoody, Danielle L. Beatty
dc.contributor.authorTaylor, Antione D.
dc.contributor.authorLeibel, Daniel K.
dc.contributor.authorAl-Najjar, Elias
dc.contributor.authorKatzel, Leslie I.
dc.contributor.authorDavatzikos, Christos
dc.contributor.authorGullapalli, Rao P.
dc.contributor.authorSeliger, Stephen L.
dc.contributor.authorKouo, Theresa
dc.contributor.authorErus, Guray
dc.contributor.authorRosenberger, William F.
dc.contributor.authorEvans, Michele K.
dc.contributor.authorZonderman, Zonderman
dc.contributor.authorWaldstein, Shari R.
dc.date.accessioned2020-01-31T15:30:49Z
dc.date.available2020-01-31T15:30:49Z
dc.date.issued2018-11-26
dc.description.abstractExplore interactive relations of lifetime discrimination burden and racial discrimination – chronic stressors among African Americans (AA) – and age with magnetic resonance imaging (MRI)-assessed white matter lesion volume (WMLV), a prognostic indicator of poor clinical brain health outcomes. Methods: AA (N= 71; 60.6% female, mean age = 50) participating in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) SCAN study underwent quantitative MRI coded for WMLV. Participants self-reported lifetime discrimination burden and racial discrimination approximately five years earlier. Multivariable regression models assessed interactions of linear and quadratic effects of discrimination and age with WMLV adjusted for sex and socioeconomic status. Results: Findings revealed significant interactive relations of age and (1) quadratic, lifetime discrimination burden, B = .05, p = .014, η²partial = .092, and (2) quadratic, racial discrimination, B = .03, p = .001, η²partial = .155 with WMLV. Among older AA, increases in lifetime discrimination burden and racial discrimination were associated with increases in WMLV (p’s < .03); in younger AA, decreasing levels of racial discrimination were related to increases in WMLV (p = .006). Conclusions: Among older AA, as lifetime discrimination burden and racial discrimination increased, so did WMLV. However, in younger AA, decreases in racial discrimination were associated with increased WMLV. Elucidation of complex mechanistic underpinnings, including potentially differential impacts of the acknowledgement versus suppression or underreporting of discriminatory experiences, among AA of different age cohorts, is critical to understanding the present pattern of findings.en_US
dc.description.sponsorshipWe would like to acknowledge our funding sources: K01AG043581 (Beatty Moody), R01AG034161 (Waldstein), the National Institute on Aging’s Intramural Research Program ZIAG000513 (Evans), and the Claude D. Pepper Older Americans Independence Center (P60-AG12583)en_US
dc.description.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483094/#__ffn_sectitleen_US
dc.format.extent2 filesen_US
dc.genrejournal articles postprintsen_US
dc.identifierdoi:10.13016/m2ygrb-haor
dc.identifier.citationMoody, Danielle L. Beatty; Taylor, Antione D.; Leibel, Daniel K.; Al-Najjar, Elias; Katzel, Leslie I.; Davatzikos, Christos; Gullapalli, Rao P.; Seliger, Stephen L.; Kouo, Theresa; Erus, Guray; Rosenberger, William F.; Evans, Michele K.; Zonderman, Zonderman; Waldstein, Shari R.; Lifetime Discrimination Burden, Racial Discrimination, and Subclinical Cerebrovascular Disease among African Americans; Health psychology : official journal of the Division of Health Psychology, American Psychological Association vol. 38,1 (2019): 63-74; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483094/#__ffn_sectitleen_US
dc.identifier.urihttps://dx.doi.org/10.1037%2Fhea0000638
dc.identifier.urihttp://hdl.handle.net/11603/17198
dc.language.isoen_USen_US
dc.publisherAmerican Physiological Associationen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Physics Department Collection
dc.relation.ispartofUMBC Mathematics and Statistics Department
dc.relation.ispartofUMBC Student Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.rights©American Psychological Association,2019. This paper is not the copy of record and may not exactly replicate the authoritative document published in the APA journal. Please do not copy or cite without author's permission. The final article is available, upon publication, at: https://dx.doi.org/10.1037%2Fhea0000638.
dc.subjectdiscrimination/racial discriminationen_US
dc.subjectageen_US
dc.subjectracial/ethnic minoritiesen_US
dc.subjectsubclinical cerebrovascular diseaseen_US
dc.subjectwhite matter lesion volume (WMLV)en_US
dc.subjectMRI-brain healthen_US
dc.titleLifetime Discrimination Burden, Racial Discrimination, and Subclinical Cerebrovascular Disease among African Americansen_US
dc.typeTexten_US

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