Metal-enhanced bioluminescence: An approach for monitoring biological luminescent processes

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dc.contributor.authorEltzov, Evgeni
dc.contributor.authorPrilutsky, Daria
dc.contributor.authorKushmaro, Ariel
dc.contributor.authorMarks, Robert S.
dc.contributor.authorGeddes, Chris
dc.date.accessioned2024-10-01T18:05:19Z
dc.date.available2024-10-01T18:05:19Z
dc.date.issued2009-02-23
dc.description.abstractIn this letter, the observation of metal (plasmon)-enhanced bioluminescence is reported. Bacteria, which are capable of generating specific bioluminescence signatures upon metabolic changes (general toxicity), have been studied from both glass and silvered glass microwell bottoms, where the silvered microwells have been modified with surface deposited silver island films (SiFs). The presence of the SiFs plasmon amplifies the near-field bioluminescence signatures, ≈<50nm from the surface, enabling amplified detection of the reporter bioluminescence indicating sample toxicity. Using our approach a greater than fivefold enhancement in far-field bioluminescence occurs with much greater enhancements in the near-field predicted.
dc.description.sponsorshipThe authors acknowledge the support of the Middle Atlantic Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research (Grant No. NIH NIAID–U54 AI057168). Salary support to authors from UMBI/MBC and the IoF is also acknowledged. D.P. thanks the Council for Higher Education for Converging Technologies, Israel, for her fellowship support.
dc.description.urihttps://pubs.aip.org/aip/apl/article/94/8/083901/337423/Metal-enhanced-bioluminescence-An-approach-for
dc.format.extent4 pages
dc.genrejournal articles
dc.identifierdoi:10.13016/m2wmsx-djvy
dc.identifier.citationEltzov, Evgeni, Daria Prilutsky, Ariel Kushmaro, Robert S. Marks, and Chris D. Geddes. “Metal-Enhanced Bioluminescence: An Approach for Monitoring Biological Luminescent Processes.” Applied Physics Letters 94, no. 8 (February 23, 2009): 083901. https://doi.org/10.1063/1.3086283.
dc.identifier.urihttps://doi.org/10.1063/1.3086283
dc.identifier.urihttp://hdl.handle.net/11603/36557
dc.language.isoen_US
dc.publisherAIP
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Chemistry & Biochemistry Department
dc.relation.ispartofUMBC Institute of Fluorescence (IoF)
dc.rightsThis article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Eltzov, Evgeni, Daria Prilutsky, Ariel Kushmaro, Robert S. Marks, and Chris D. Geddes. “Metal-Enhanced Bioluminescence: An Approach for Monitoring Biological Luminescent Processes.” Applied Physics Letters 94, no. 8 (February 23, 2009): 083901. https://doi.org/10.1063/1.3086283 and may be found at https://pubs.aip.org/aip/apl/article/94/8/083901/337423/Metal-enhanced-bioluminescence-An-approach-for.
dc.titleMetal-enhanced bioluminescence: An approach for monitoring biological luminescent processes
dc.typeText
dcterms.creatorhttps://orcid.org/0000-0002-9110-6374

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