COMPARISON OF ALPHA-SYNUCLEIN AGGREGATION KINETICS IN THE PRESENCE OF LIMP-2 OVEREXPRESSION IN PARKINSONS DISEASE MODEL.
| dc.contributor.advisor | Beyer, Rachel | |
| dc.contributor.author | Aldhubayb, Meshal | |
| dc.date.accessioned | 2018-12-20T13:39:32Z | |
| dc.date.available | 2018-12-20T13:39:32Z | |
| dc.date.issued | 2018-12-19 | |
| dc.description | In this study, we investigate the role of LIMP-2 in decreasing the cytotoxicity of the alpha-synuclein in the familial mutations of the alpha-synuclein in Parkinson’s disease models. | en_US |
| dc.description.abstract | Parkinson’s disease is a slow aggressive neurological disorder characterized by loss of dopamine in substantia nigra which is located in the brain and formats a neuronal cytotoxic protein called alpha- synuclein. Researchers found that genetics plays a significant role in formation of alpha-synuclein aggregation. Studies of families with the history of Parkinson’s disease have identificatied of familial mutations (A30P, E46K, H50Q, G51D, A53T). Researchers have tried to prevent alpha-synuclein aggregation as a way to treat Parkinson’s disease. One possible and promising way to prevent aggregation is overexpression of the lysosomal Integral Membrane Protein type-2 (LIMP-2). In this project, I propose to investigate the role of LIMP-2 in the familial mutation of Parkinson’s diseases. This project uses cellular models for each of the familial mutations for Parkinson’s diseases, inserts of plasmids that contain the LIMP-2 to these cellular models to investigate the effect of the LIMP-2 added on proved aggregation in the familial mutations, and monitor alpha-synuclein aggregation by using Fluorescence Resonance Energy Transfer (FRET) to measure it. | en_US |
| dc.identifier | doi:10.13016/m2wgxg-8t91 | |
| dc.identifier.uri | http://hdl.handle.net/11603/12327 | |
| dc.language.iso | en_US | en_US |
| dc.relation.isAvailableAt | Hood College | |
| dc.rights | Attribution-NonCommercial 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/us/ | * |
| dc.subject | ALPHA-SYNUCLEIN AGGREGATION | en_US |
| dc.title | COMPARISON OF ALPHA-SYNUCLEIN AGGREGATION KINETICS IN THE PRESENCE OF LIMP-2 OVEREXPRESSION IN PARKINSONS DISEASE MODEL. | en_US |
| dc.type | Collection | en_US |
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