HOW LINEAR ELASTIC MATERIAL PROPERTIES AFFECT LUNG TUMOR MOTION AND DEFORMATION: A FINITE ELEMENT ANALYSIS.

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dc.contributor.advisorTopoleski, L.D. Timmie
dc.contributor.authorRay, Noelle
dc.contributor.departmentMechanical Engineering
dc.contributor.programEngineering, Mechanical
dc.date.accessioned2023-07-31T20:00:10Z
dc.date.available2023-07-31T20:00:10Z
dc.date.issued2023-01-01
dc.description.abstractRespiratory motion is a complication for radiation treatment (RT) of lung cancer. A moving and deforming tumor is difficult to radiate with a stationary beam. The tumor will not receive the entire radiation dose and healthy tissue will be exposed to the radiation. Management techniques like surrogate motion models (SMMs) have been developed to help mitigate this problem by using 4-Dimensional CT (4DCT) scans to predict tumor motion during the RT. These SMMs frequently use approximated material property values for the lungs and tumor(s); however, errors caused by using incorrect values are rarely investigated. This work presents an examination of the effect material properties have on tumor movement and deformation using a finite element (FE) model of the lung and tumor in COMSOL. A range of values was assigned to density, Poisson?s ratio, and elastic modulus for the lung and the tumor. Lung density showed no effect on tumor movement or deformation. Displacement differences between material property values ranged from 0.0043- 1.5304cm. The lung elastic modulus has the greatest effect on tumor displacement, with a range of 1.5cm. Lung Poisson?s ratio values affected displacement with a maximum displacement range of 0.1942cm. Tumor elastic modulus and Poisson?s ratio showed insignificant effects on displacement of the tumor. It was concluded that the elastic modulus value for the lung should be a personalized approximation to provide optimal modeling results in SMMs, thereby maximizing the radiation dose to the tumor, minimizing radiation dose to the healthy tissue, and improving the life of the patient.
dc.formatapplication:pdf
dc.genrethesis
dc.identifierdoi:10.13016/m2db3d-4hnd
dc.identifier.other12681
dc.identifier.urihttp://hdl.handle.net/11603/28972
dc.languageen
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Mechanical Engineering Department Collection
dc.relation.ispartofUMBC Theses and Dissertations Collection
dc.relation.ispartofUMBC Graduate School Collection
dc.relation.ispartofUMBC Student Collection
dc.rightsThis item may be protected under Title 17 of the U.S. Copyright Law. It is made available by UMBC for non-commercial research and education. For permission to publish or reproduce, please see http://aok.lib.umbc.edu/specoll/repro.php or contact Special Collections at speccoll(at)umbc.edu
dc.sourceOriginal File Name: Ray_umbc_0434M_12681.pdf
dc.subjectCOMSOL
dc.subjectFinite element
dc.subjectLung
dc.subjectlung cancer
dc.subjectmaterial properties
dc.subjecttumor
dc.titleHOW LINEAR ELASTIC MATERIAL PROPERTIES AFFECT LUNG TUMOR MOTION AND DEFORMATION: A FINITE ELEMENT ANALYSIS.
dc.typeText
dcterms.accessRightsAccess limited to the UMBC community. Item may possibly be obtained via Interlibrary Loan through a local library, pending author/copyright holder's permission.
dcterms.accessRightsAccess limited to the UMBC community. Item may possibly be obtained via Interlibrary Loan thorugh a local library, pending author/copyright holder's permission.

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