HOW LINEAR ELASTIC MATERIAL PROPERTIES AFFECT LUNG TUMOR MOTION AND DEFORMATION: A FINITE ELEMENT ANALYSIS.

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Ray_umbc_0434M_12681.pdf (1.63 MB)

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http://hdl.handle.net/11603/28972

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UMBC Theses and Dissertations
UMBC Graduate School
UMBC Mechanical Engineering Department
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Date

2023-01-01

Type of Work

thesis
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application:pdf

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Mechanical Engineering

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Engineering, Mechanical

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This item may be protected under Title 17 of the U.S. Copyright Law. It is made available by UMBC for non-commercial research and education. For permission to publish or reproduce, please see http://aok.lib.umbc.edu/specoll/repro.php or contact Special Collections at speccoll(at)umbc.edu
Access limited to the UMBC community. Item may possibly be obtained via Interlibrary Loan through a local library, pending author/copyright holder's permission.
Access limited to the UMBC community. Item may possibly be obtained via Interlibrary Loan thorugh a local library, pending author/copyright holder's permission.

Subjects

COMSOL
Finite element
Lung
lung cancer
material properties
tumor

Abstract

Respiratory motion is a complication for radiation treatment (RT) of lung cancer. A moving and deforming tumor is difficult to radiate with a stationary beam. The tumor will not receive the entire radiation dose and healthy tissue will be exposed to the radiation. Management techniques like surrogate motion models (SMMs) have been developed to help mitigate this problem by using 4-Dimensional CT (4DCT) scans to predict tumor motion during the RT. These SMMs frequently use approximated material property values for the lungs and tumor(s); however, errors caused by using incorrect values are rarely investigated. This work presents an examination of the effect material properties have on tumor movement and deformation using a finite element (FE) model of the lung and tumor in COMSOL. A range of values was assigned to density, Poisson?s ratio, and elastic modulus for the lung and the tumor. Lung density showed no effect on tumor movement or deformation. Displacement differences between material property values ranged from 0.0043- 1.5304cm. The lung elastic modulus has the greatest effect on tumor displacement, with a range of 1.5cm. Lung Poisson?s ratio values affected displacement with a maximum displacement range of 0.1942cm. Tumor elastic modulus and Poisson?s ratio showed insignificant effects on displacement of the tumor. It was concluded that the elastic modulus value for the lung should be a personalized approximation to provide optimal modeling results in SMMs, thereby maximizing the radiation dose to the tumor, minimizing radiation dose to the healthy tissue, and improving the life of the patient.