Flex-nucleoside analogues – Novel therapeutics against filoviruses

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 1s2.0S0960894X17304456mmc1.pdf (1.06 MB)

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https://www.sciencedirect.com/science/article/pii/S0960894X17304456?via%3Dihub

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https://doi.org/10.1016/j.bmcl.2017.04.069
 http://hdl.handle.net/11603/39581

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UMBC Chemistry & Biochemistry Department
UMBC Faculty Collection
UMBC Graduate School

Author/Creator

Author/Creator ORCID

https://orcid.org/0000-0002-0154-3459

Date

2017-04-21

Type of Work

journal articles
postprints
Text

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Program

Citation of Original Publication

Yates, Mary K., Mithun R. Raje, Payel Chatterjee, Christina F. Spiropoulou, Sina Bavari, Mike Flint, Veronica Soloveva, and Katherine L. Seley-Radtke. “Flex-Nucleoside Analogues – Novel Therapeutics against Filoviruses.” Bioorganic & Medicinal Chemistry Letters 27, no. 12 (June 15, 2017): 2800–2802. https://doi.org/10.1016/j.bmcl.2017.04.069.

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Creative Commons Attribution Non-Commercial No Derivatives License

Subjects

Filovirus
Nucleoside
Fleximers
Antiviral
Ebola

Abstract

Fleximers, a novel type of flexible nucleoside that have garnered attention due to their unprecedented activity against human coronaviruses, have now exhibited highly promising levels of activity against filoviruses. The Flex-nucleoside was the most potent against recombinant Ebola virus in Huh7 cells with an EC₅₀=2μM, while the McGuigan prodrug was most active against Sudan virus-infected HeLa cells with an EC₅₀ of 7μM.