Flex-nucleoside analogues – Novel therapeutics against filoviruses

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dc.contributor.authorYates, Mary Kendall
dc.contributor.authorRaje, Mithun R.
dc.contributor.authorChatterjee, Payel
dc.contributor.authorSpiropoulou, Christina F.
dc.contributor.authorBavari, Sina
dc.contributor.authorFlint, Mike
dc.contributor.authorSoloveva, Veronica
dc.contributor.authorSeley-Radtke, Katherine
dc.date.accessioned2025-07-30T19:22:40Z
dc.date.issued2017-04-21
dc.description.abstractFleximers, a novel type of flexible nucleoside that have garnered attention due to their unprecedented activity against human coronaviruses, have now exhibited highly promising levels of activity against filoviruses. The Flex-nucleoside was the most potent against recombinant Ebola virus in Huh7 cells with an EC₅₀=2μM, while the McGuigan prodrug was most active against Sudan virus-infected HeLa cells with an EC₅₀ of 7μM.
dc.description.sponsorshipThis work was supported by the National Institutes of Health - T32 GM066706 and R21 AI097685 (KSR). We would also like to thank USAMRIID/MTS colleagues Dima Gharaibeh, Ylenia Cau, Tara Kenny, Cary Retterer, Rouzbeh Zamani, Glenn Gomba and Collin Dube for assistance. Work at USAMRIID was funded by The Joint Science and Technology Office for Chemical and Biological Defense (JSTO-CBD) of the Defense Threat Reduction Agency (DTRA).
dc.description.urihttps://www.sciencedirect.com/science/article/pii/S0960894X17304456?via%3Dihub
dc.format.extent5 pages
dc.genrejournal articles
dc.genrepostprints
dc.identifierdoi:10.13016/m2lvxf-fuy0
dc.identifier.citationYates, Mary K., Mithun R. Raje, Payel Chatterjee, Christina F. Spiropoulou, Sina Bavari, Mike Flint, Veronica Soloveva, and Katherine L. Seley-Radtke. “Flex-Nucleoside Analogues – Novel Therapeutics against Filoviruses.” Bioorganic & Medicinal Chemistry Letters 27, no. 12 (June 15, 2017): 2800–2802. https://doi.org/10.1016/j.bmcl.2017.04.069.
dc.identifier.urihttps://doi.org/10.1016/j.bmcl.2017.04.069
dc.identifier.urihttp://hdl.handle.net/11603/39581
dc.language.isoen_US
dc.publisherElsevier
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Student Collection
dc.relation.ispartofUMBC Chemistry & Biochemistry Department
dc.relation.ispartofUMBC Faculty Collection
dc.relation.ispartofUMBC Graduate School
dc.rightsCreative Commons Attribution Non-Commercial No Derivatives License
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.en
dc.subjectFilovirus
dc.subjectNucleoside
dc.subjectFleximers
dc.subjectAntiviral
dc.subjectEbola
dc.titleFlex-nucleoside analogues – Novel therapeutics against filoviruses
dc.typeText
dcterms.creatorhttps://orcid.org/0000-0002-0154-3459

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