Development of a portable Raman spectrometer for medical diagnostics

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https://www.spiedigitallibrary.org/conference-proceedings-of-spie/4615/0000/Development-of-a-portable-Raman-spectrometer-for-medical-diagnostics/10.1117/12.466637.full

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https://doi.org/10.1117/12.466637
 http://hdl.handle.net/11603/35964

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UMBC Chemistry & Biochemistry Department

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https://orcid.org/0000-0002-5250-8290

Date

2002-05-13

Type of Work

conference papers and proceedings
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Citation of Original Publication

Cullum, Brian M., Joel Mobley, David L. Stokes, Leonardo R. Allain, Dimitra N. Stratis, Alan L. Wintenberg, R. A. Maples, and Tuan Vo-Dinh. “Development of a Portable Raman Spectrometer for Medical Diagnostics.” In Biomedical Diagnostic, Guidance, and Surgical-Assist Systems IV, 4615. (May 13, 2002):82–90. https://doi.org/10.1117/12.466637.

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THIS WORK WAS WRITTEN AS PART OF ONE OF THE AUTHOR'S OFFICIAL DUTIES AS AN EMPLOYEE OF THE UNITED STATES GOVERNMENT AND IS THEREFORE A WORK OF THE UNITED STATES GOVERNMENT. IN ACCORDANCE WITH 17 U.S.C. 105, NO COPYRIGHT PROTECTION IS AVAILABLE FOR SUCH WORKS UNDER U.S. LAW.
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Abstract

This paper describes a self-contained, portable Raman instrument that has been developed for biomedical analyses. The instrument consists of a 785-nm diode laser for excitation, an acousto-optic tunable filter (AOTF) for wavelength discrimination, and an avalanche photodiode for detection. The primary component of this system is the AOTF and it has been selected based on its spectral range along with its high resolution, approximately 7.5 cm⁻¹. Software has been developed in-house in the programming language of C for controlling the instrument (i.e., the AOTF frequency, the signal acquisition, etc.). Evaluation of this instrument has been performed by analyzing several standard samples and comparing their spectra to spectra acquired using a conventional laboratory system. In addition to system evaluation, this paper will also discuss potential applications of this instrument to multiplexed genechip types of analyses.