Development of a portable Raman spectrometer for medical diagnostics

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dc.contributor.authorCullum, Brian
dc.contributor.authorMobley, Joel
dc.contributor.authorStokes, David L.
dc.contributor.authorAllain, Leonardo R.
dc.contributor.authorStratis, Dimitra N.
dc.contributor.authorWintenberg, Alan L.
dc.contributor.authorMaples, R. A.
dc.contributor.authorVo-Dinh, Tuan
dc.date.accessioned2024-09-04T19:58:28Z
dc.date.available2024-09-04T19:58:28Z
dc.date.issued2002-05-13
dc.descriptionInternational Symposium on Biomedical Optics, 2002, San Jose, CA, United States
dc.description.abstractThis paper describes a self-contained, portable Raman instrument that has been developed for biomedical analyses. The instrument consists of a 785-nm diode laser for excitation, an acousto-optic tunable filter (AOTF) for wavelength discrimination, and an avalanche photodiode for detection. The primary component of this system is the AOTF and it has been selected based on its spectral range along with its high resolution, approximately 7.5 cm⁻¹. Software has been developed in-house in the programming language of C for controlling the instrument (i.e., the AOTF frequency, the signal acquisition, etc.). Evaluation of this instrument has been performed by analyzing several standard samples and comparing their spectra to spectra acquired using a conventional laboratory system. In addition to system evaluation, this paper will also discuss potential applications of this instrument to multiplexed genechip types of analyses.
dc.description.sponsorshipThis research is sponsored by the U.S. Department of Energy under contract DE-AC05-00OR22725 (NN-20 Program) with Lockheed Martin Energy Research Corp. B. M. Cullum, J. Mobley, D. L. Stokes, L. R. Allain and D. N. Stratis are also supported by an appointment to the Oak Ridge National Laboratory Postdoctoral Research Program administered jointly by the Oak Ridge Institute for Science and Education and Oak Ridge National Laboratory.
dc.description.urihttps://www.spiedigitallibrary.org/conference-proceedings-of-spie/4615/0000/Development-of-a-portable-Raman-spectrometer-for-medical-diagnostics/10.1117/12.466637.full
dc.format.extent9 pages
dc.genreconference papers and proceedings
dc.identifierdoi:10.13016/m2fufn-fopn
dc.identifier.citationCullum, Brian M., Joel Mobley, David L. Stokes, Leonardo R. Allain, Dimitra N. Stratis, Alan L. Wintenberg, R. A. Maples, and Tuan Vo-Dinh. “Development of a Portable Raman Spectrometer for Medical Diagnostics.” In Biomedical Diagnostic, Guidance, and Surgical-Assist Systems IV, 4615. (May 13, 2002):82–90. https://doi.org/10.1117/12.466637.
dc.identifier.urihttps://doi.org/10.1117/12.466637
dc.identifier.urihttp://hdl.handle.net/11603/35964
dc.language.isoen_US
dc.publisherSPIE
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Chemistry & Biochemistry Department
dc.rightsTHIS WORK WAS WRITTEN AS PART OF ONE OF THE AUTHOR'S OFFICIAL DUTIES AS AN EMPLOYEE OF THE UNITED STATES GOVERNMENT AND IS THEREFORE A WORK OF THE UNITED STATES GOVERNMENT. IN ACCORDANCE WITH 17 U.S.C. 105, NO COPYRIGHT PROTECTION IS AVAILABLE FOR SUCH WORKS UNDER U.S. LAW.
dc.rightsPUBLIC DOMAIN
dc.rights.urihttps://creativecommons.org/publicdomain/mark/1.0/
dc.titleDevelopment of a portable Raman spectrometer for medical diagnostics
dc.typeText
dcterms.creatorhttps://orcid.org/0000-0002-5250-8290

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