The histone methyltransferases Set5 and Set1 have overlapping functions in gene silencing and telomere maintenance

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dc.contributor.authorJezek, Meagan
dc.contributor.authorGast, Alison
dc.contributor.authorChoi, Grace
dc.contributor.authorKulkarni, Rushmie
dc.contributor.authorQuijote, Jeremiah
dc.contributor.authorGraham-Yooll, Andrew
dc.contributor.authorPark, DoHwan
dc.contributor.authorGreen, Erin
dc.date.accessioned2023-01-25T15:07:29Z
dc.date.available2023-01-25T15:07:29Z
dc.date.issued2016-12-02
dc.description.abstractGenes adjacent to telomeres are subject to transcriptional repression mediated by an integrated set of chromatin modifying and remodeling factors. The telomeres of Saccharomyces cerevisiae have served as a model for dissecting the function of diverse chromatin proteins in gene silencing, and their study has revealed overlapping roles for many chromatin proteins in either promoting or antagonizing gene repression. The H3K4 methyltransferase Set1, which is commonly linked to transcriptional activation, has been implicated in telomere silencing. Set5 is an H4 K5, K8, and K12 methyltransferase that functions with Set1 to promote repression at telomeres. Here, we analyzed the combined role for Set1 and Set5 in gene expression control at native yeast telomeres. Our data reveal that Set1 and Set5 promote a Sir protein-independent mechanism of repression that may primarily rely on regulation of H4K5ac and H4K8ac at telomeric regions. Furthermore, cells lacking both Set1 and Set5 have highly correlated transcriptomes to mutants in telomere maintenance pathways and display defects in telomere stability, linking their roles in silencing to protection of telomeres. Our data therefore provide insight into and clarify potential mechanisms by which Set1 contributes to telomere silencing and shed light on the function of Set5 at telomeres.en_US
dc.description.sponsorshipThis work was supported in part by NIH grant R03AG052018 to E.M.G. and by an Undergraduate Biology and Mathematics NSF training grant number 1031420 to the Departments of Biological Sciences and Mathematics and Statistics at UMBC.en_US
dc.description.urincbi.nlm.nih.gov/pmc/articles/PMC5330434/en_US
dc.format.extent12 pagesen_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/m2s8af-ffqi
dc.identifier.citationJezek, Meagan et al. “The histone methyltransferases Set5 and Set1 have overlapping functions in gene silencing and telomere maintenance.” Epigenetics 12, no. 2 (2017): 93-104. doi:10.1080/15592294.2016.1265712en_US
dc.identifier.urihttps://doi.org/10.1080%2F15592294.2016.1265712
dc.identifier.urihttp://hdl.handle.net/11603/26701
dc.language.isoen_USen_US
dc.publisherTaylor & Francisen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Biological Sciences Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.relation.ispartofUMBC Student Collection
dc.relation.ispartofUMBC Mathematics and Statistics Department
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.en_US
dc.subjectGene silencingen_US
dc.subjecthistone acetylationen_US
dc.subjecthistone methylationen_US
dc.subjectSet1en_US
dc.subjectSet5en_US
dc.subjecttelomere maintenanceen_US
dc.subjecttelomeresen_US
dc.titleThe histone methyltransferases Set5 and Set1 have overlapping functions in gene silencing and telomere maintenanceen_US
dc.typeTexten_US
dcterms.creatorhttps://orcid.org/0000-0002-9132-5040en_US
dcterms.creatorhttps://orcid.org/0000-0003-3923-6726en_US

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