Modeling the Links Between the Chemical, Electrical and Contractile Calcium Dynamics in a Heart Cell

Simple item page
dc.contributor.authorAngeloff, Kallista
dc.contributor.authorBarajas, Carlos
dc.contributor.authorMiddleton, Alexander
dc.contributor.authorOsia, Uchenna
dc.contributor.authorGraf, Jonathan S.
dc.contributor.authorGobbert, Matthias K.
dc.contributor.authorCoulibaly, Zana
dc.date.accessioned2018-09-20T18:52:45Z
dc.date.available2018-09-20T18:52:45Z
dc.date.issued2016
dc.description.abstractCalcium dysregulation is a signi cant cause of fatal cardiac arrythmias, but it is an incompletely understood phenomenon and diffcult to predict. Cardiac calcium levels can be modelled as a system of partial differential equations linking the electrical, calcium, and mechanical dynamics of the heart. Earlier work on this subject established a model linking the chemical and electrical systems, which did not include the contractile or mechanical in uence. We have expanded the most recent extant model to include the mechanical aspect of calcium dynamics in the heart.en_US
dc.description.sponsorshipThese results were obtained as part of the REU Site: Interdisciplinary Program in High Performance Computing (hpcreu.umbc.edu) in the Department of Mathematics and Statistics at the University of Maryland, Baltimore County (UMBC), in Summer 2016. This program is funded by the National Science Foundation (NSF), the National Security Agency (NSA), and the Department of Defense (DOD), with additional support from UMBC, the Department of Mathematics and Statistics, the Center for Interdisciplinary Research and Consulting (CIRC), and the UMBC High Performance Computing Facility (HPCF). HPCF is supported by the U.S. National Science Foundation through the MRI program (grant nos. CNS{0821258 and CNS (1228778) and the SCREMS program (grant no. DMS{0821311), with additional substantial support from UMBC. Co-author Uchenna Osia was supported in part by the UMBC National Security Agency (NSA) Scholars Program through a contract with the NSA. Graduate assistant Jonathan Graf was supported by UMBC.en_US
dc.description.urihttps://userpages.umbc.edu/~gobbert/papers/REU2016Team5.pdfen_US
dc.format.extent32 pagesen_US
dc.genretechnical reporten_US
dc.identifierdoi:10.13016/M2GX44Z3G
dc.identifier.urihttp://hdl.handle.net/11603/11334
dc.language.isoen_USen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Mathematics Department Collection
dc.relation.ispartofUMBC Student Collection
dc.relation.ispartofUMBC Faculty Collection
dc.relation.ispartofseriesHPCF Technical Report;HPCF-2016-15
dc.rightsThis item may be protected under Title 17 of the U.S. Copyright Law. It is made available by UMBC for non-commercial research and education. For permission to publish or reproduce, please contact the author.
dc.subjectCalcium-induced calcium releaseen_US
dc.subjectCardiomyocytesen_US
dc.subjectContractile cardiac dynamicsen_US
dc.subjectChemical cardiac dynamicsen_US
dc.subjectElectrical cardiac dynamicsen_US
dc.subjectUMBC High Performance Computing Facility (HPCF)en_US
dc.titleModeling the Links Between the Chemical, Electrical and Contractile Calcium Dynamics in a Heart Cellen_US
dc.typeTexten_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
REU2016Team5.pdf
Size:
18.17 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.68 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

UMBC Mathematics and Statistics Department
UMBC Faculty Collection
UMBC Student Collection