Modeling the Links Between the Chemical, Electrical and Contractile Calcium Dynamics in a Heart Cell
dc.contributor.author | Angeloff, Kallista | |
dc.contributor.author | Barajas, Carlos | |
dc.contributor.author | Middleton, Alexander | |
dc.contributor.author | Osia, Uchenna | |
dc.contributor.author | Graf, Jonathan S. | |
dc.contributor.author | Gobbert, Matthias K. | |
dc.contributor.author | Coulibaly, Zana | |
dc.date.accessioned | 2018-09-20T18:52:45Z | |
dc.date.available | 2018-09-20T18:52:45Z | |
dc.date.issued | 2016 | |
dc.description.abstract | Calcium dysregulation is a signi cant cause of fatal cardiac arrythmias, but it is an incompletely understood phenomenon and diffcult to predict. Cardiac calcium levels can be modelled as a system of partial differential equations linking the electrical, calcium, and mechanical dynamics of the heart. Earlier work on this subject established a model linking the chemical and electrical systems, which did not include the contractile or mechanical in uence. We have expanded the most recent extant model to include the mechanical aspect of calcium dynamics in the heart. | en_US |
dc.description.sponsorship | These results were obtained as part of the REU Site: Interdisciplinary Program in High Performance Computing (hpcreu.umbc.edu) in the Department of Mathematics and Statistics at the University of Maryland, Baltimore County (UMBC), in Summer 2016. This program is funded by the National Science Foundation (NSF), the National Security Agency (NSA), and the Department of Defense (DOD), with additional support from UMBC, the Department of Mathematics and Statistics, the Center for Interdisciplinary Research and Consulting (CIRC), and the UMBC High Performance Computing Facility (HPCF). HPCF is supported by the U.S. National Science Foundation through the MRI program (grant nos. CNS{0821258 and CNS (1228778) and the SCREMS program (grant no. DMS{0821311), with additional substantial support from UMBC. Co-author Uchenna Osia was supported in part by the UMBC National Security Agency (NSA) Scholars Program through a contract with the NSA. Graduate assistant Jonathan Graf was supported by UMBC. | en_US |
dc.description.uri | https://userpages.umbc.edu/~gobbert/papers/REU2016Team5.pdf | en_US |
dc.format.extent | 32 pages | en_US |
dc.genre | technical report | en_US |
dc.identifier | doi:10.13016/M2GX44Z3G | |
dc.identifier.uri | http://hdl.handle.net/11603/11334 | |
dc.language.iso | en_US | en_US |
dc.relation.isAvailableAt | The University of Maryland, Baltimore County (UMBC) | |
dc.relation.ispartof | UMBC Mathematics Department Collection | |
dc.relation.ispartof | UMBC Student Collection | |
dc.relation.ispartof | UMBC Faculty Collection | |
dc.relation.ispartofseries | HPCF Technical Report;HPCF-2016-15 | |
dc.rights | This item may be protected under Title 17 of the U.S. Copyright Law. It is made available by UMBC for non-commercial research and education. For permission to publish or reproduce, please contact the author. | |
dc.subject | Calcium-induced calcium release | en_US |
dc.subject | Cardiomyocytes | en_US |
dc.subject | Contractile cardiac dynamics | en_US |
dc.subject | Chemical cardiac dynamics | en_US |
dc.subject | Electrical cardiac dynamics | en_US |
dc.subject | UMBC High Performance Computing Facility (HPCF) | en_US |
dc.title | Modeling the Links Between the Chemical, Electrical and Contractile Calcium Dynamics in a Heart Cell | en_US |
dc.type | Text | en_US |