Effects of prefrontal cortical lesions on neuropeptide and dopamine receptor gene expression in the striatum-accumbens complex

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dc.contributor.authorBaca, Serapio M.
dc.contributor.authorLipska, Barbara K.
dc.contributor.authorEgan, Michael F.
dc.contributor.authorBachus, Susan E.
dc.contributor.authorFerguson, Jennifer N.
dc.contributor.authorHyde, Thomas M.
dc.date.accessioned2020-04-09T17:21:32Z
dc.date.available2020-04-09T17:21:32Z
dc.date.issued1998-06-25
dc.description.abstractIn the rat, neurochemical, behavioral, and anatomical investigations suggest that medial prefrontal cortical input modulates the activity of the basal ganglia. To understand how prefrontal dysfunction might alter striatal-accumbens function, in situ hybridization histochemistry with S³⁵-labeled oligonucleotide probes was used to assess changes in striatal-accumbens gene expression following bilateral excitotoxic ibotenic acid (IA) lesions of the rat medial prefrontal cortex. Quantitative densitometry was used to measure changes in mRNA levels for preproenkephalin A (ENK), D1 dopamine receptor, protachykinin (SubP), glutamic acid decarboxylase (GAD65), and D2 dopamine receptor. No differences were found between sham and lesion groups for ENK, D1, SubP, or GAD65 mRNA levels in the striatum or nucleus accumbens (NAC). D2 receptor mRNA levels were, however, significantly higher in the dorsomedial striatum and in the core area of the NAC of the lesioned rats. Although the functional significance of increased D2 mRNA is unclear, these findings demonstrate that glutamate mPFC projections modulate gene expression in relatively regionally-localized subcortical neuronal populations.en_US
dc.description.urihttps://www.sciencedirect.com/science/article/abs/pii/S0006899398003436?via%3Dihuben_US
dc.format.extent10 pagesen_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/m2ixgi-nw2u
dc.identifier.citationBaca, Serapio M.; Lipska, Barbara K.; Egan, Michael F.; Bachus, Susan E.; Ferguson, Jennifer N.; Hyde, Thomas M.; Effects of prefrontal cortical lesions on neuropeptide and dopamine receptor gene expression in the striatum-accumbens complex; Brain Research 797(1), pages 55-64(1998); https://www.sciencedirect.com/science/article/abs/pii/S0006899398003436?via%3Dihuben_US
dc.identifier.urihttps://doi.org/10.1016/S0006-8993(98)00343-6
dc.identifier.urihttp://hdl.handle.net/11603/17909
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Psychology Department Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.rightsPublic Domain Mark 1.0*
dc.rightsThis work was written as part of one of the author's official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.
dc.rights.urihttp://creativecommons.org/publicdomain/mark/1.0/*
dc.titleEffects of prefrontal cortical lesions on neuropeptide and dopamine receptor gene expression in the striatum-accumbens complexen_US
dc.typeTexten_US

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