Angle-Tuned Coils: Attractive Building Blocks for TMS with Improved Depth-Spread Performance

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dc.contributor.authorBagherzadeh, Hedyeh
dc.contributor.authorMeng, Qinglei
dc.contributor.authorDeng, Zhi-De
dc.contributor.authorLu, Hanbing
dc.contributor.authorHong, Elliott
dc.contributor.authorYang, Yihong
dc.contributor.authorChoa, Fow-Sen
dc.date.accessioned2022-06-21T21:27:10Z
dc.date.available2022-06-21T21:27:10Z
dc.date.issued2022-05-04
dc.description.abstractObjective. A novel angle-tuned ring coil is proposed for improving the depth-spread performance of transcranial magnetic stimulation (TMS) coils and serve as the building blocks for high-performance composite coils and multisite TMS systems. Approach. Improving depth-spread performance by reducing field divergence through creating a more elliptical emitted field distribution from the coil. To accomplish that, instead of enriching the Fourier components along the planarized (x-y) directions, which requires different arrays to occupy large brain surface areas, we worked along the radial (z) direction by using tilted coil angles and stacking coil numbers to reduce the divergence of the emitted near field without occupying large head surface areas. The emitted electric field distributions were theoretically simulated in spherical and real human head models to analyze the depth-spread performance of proposed coils and compare with existing figure-8 coils. The results were then experimentally validated with field probes and in-vivo animal tests. Main results. The proposed 'angle-tuning' concept improves the depth-spread performance of individual coils with a significantly smaller footprint than existing and proposed coils. For composite structures, using the proposed coils as basic building blocks simplifies the design and manufacturing process and helps accomplish a leading depth-spread performance. In addition, the footprint of the proposed system is intrinsically small, making them suitable for multisite stimulations of inter and intra-hemispheric brain regions with an improved spread and less electric field divergence. Significance. Few brain functions are operated by isolated single brain regions but rather by coordinated networks involving multiple brain regions. Simultaneous or sequential multisite stimulations may provide tools for mechanistic studies of brain functions and the treatment of neuropsychiatric disorders. The proposed AT coil goes beyond the traditional depth-spread tradeoff rule of TMS coils, which provides the possibility of building new composite structures and new multisite TMS tools.en_US
dc.description.sponsorshipThe research was supported by the NSF Grant ECCS-1631820, NIH Grants MH112180, MH108148, MH103222, and a Brain and Behavior Research Foundation grant. It was also partly supported by the Intramural Research Program of the National Institute on Drug Abuse, National Institutes of Health. In addition, Z D is supported by the National Institute of Mental Health Intramural Research Program (ZIAMH002955).en_US
dc.description.urihttps://iopscience.iop.org/article/10.1088/1741-2552/ac697c/metaen_US
dc.format.extent13 pagesen_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/m2flb1-vz5e
dc.identifier.citationHedyeh Bagherzadeh et al 2022 J. Neural Eng. in press https://doi.org/10.1088/1741-2552/ac697cen_US
dc.identifier.urihttps://doi.org/10.1088/1741-2552/ac697c
dc.identifier.urihttp://hdl.handle.net/11603/25007
dc.language.isoen_USen_US
dc.publisherIOPen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Computer Science and Electrical Engineering Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.relation.ispartofUMBC Student Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.en_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rightsAccess to this item will begin on date 4/22/23.
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.titleAngle-Tuned Coils: Attractive Building Blocks for TMS with Improved Depth-Spread Performanceen_US
dc.typeTexten_US
dcterms.creatorhttps://orcid.org/0000-0002-4646-5212en_US
dcterms.creatorhttps://orcid.org/0000-0001-9613-6110en_US

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