Polyurethane Nanocapsules in TBI Treatment

Abstract

This study investigates the development and application of polyurethane nanocapsules for the controlled delivery and release of neuroprotective drugs such as Epigallocatechin Gallate (EGCG) and Tempol with the objective of treating Traumatic Brain Injuries (TBIs). TBIs, a major health issue, causing considerable effects on individuals and healthcare systems globally, require innovative treatment approaches due to the intricate nature of the injury and the challenges in delivering drugs across the blood-brain barrier (BBB). This thesis outlines the process of synthesis of polyurethane nanocapsules encapsulating EGCG and Tempol, leveraging their antioxidant and anti-inflammatory properties to reduce the secondary injury phase after a traumatic brain injury. The properties of the nanocapsules were analyzed using dynamic light scattering (DLS), transmission electron microscopy (TEM), and Fourier-transform infrared (FTIR) spectroscopy. The in-vitro release studies highlighted these nanocapsules' potential for both sustained and on-demand drug release, addressing the need for long-term treatment and adaptability in TBI management. This study highlights the potential of drug delivery systems enhanced with nanotechnology in overcoming the blood-brain barrier and improving therapeutic outcomes for TBI patients, paving the way for future clinical applications and advancements in neurotherapeutic interventions.