Polyurethane Nanocapsules in TBI Treatment

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Primary Ale_umbc_0434M_12873.pdf (2.5 MB)

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http://hdl.handle.net/11603/35331

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UMBC Theses and Dissertations
UMBC Graduate School
UMBC Mechanical Engineering Department
UMBC Student Collection

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Author/Creator ORCID

Date

2024-01-01

Type of Work

thesis
Text
application:pdf

Department

Mechanical Engineering

Program

Engineering, Mechanical

Citation of Original Publication

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This item may be protected under Title 17 of the U.S. Copyright Law. It is made available by UMBC for non-commercial research and education. For permission to publish or reproduce, please see http://aok.lib.umbc.edu/specoll/repro.php or contact Special Collections at speccoll(at)umbc.edu
Distribution Rights granted to UMBC by the author.

Subjects

Abstract

This study investigates the development and application of polyurethane nanocapsules for the controlled delivery and release of neuroprotective drugs such as Epigallocatechin Gallate (EGCG) and Tempol with the objective of treating Traumatic Brain Injuries (TBIs). TBIs, a major health issue, causing considerable effects on individuals and healthcare systems globally, require innovative treatment approaches due to the intricate nature of the injury and the challenges in delivering drugs across the blood-brain barrier (BBB). This thesis outlines the process of synthesis of polyurethane nanocapsules encapsulating EGCG and Tempol, leveraging their antioxidant and anti-inflammatory properties to reduce the secondary injury phase after a traumatic brain injury. The properties of the nanocapsules were analyzed using dynamic light scattering (DLS), transmission electron microscopy (TEM), and Fourier-transform infrared (FTIR) spectroscopy. The in-vitro release studies highlighted these nanocapsules' potential for both sustained and on-demand drug release, addressing the need for long-term treatment and adaptability in TBI management. This study highlights the potential of drug delivery systems enhanced with nanotechnology in overcoming the blood-brain barrier and improving therapeutic outcomes for TBI patients, paving the way for future clinical applications and advancements in neurotherapeutic interventions.