Hetero-expanded Purine Nucleosides. Design, Synthesis and Preliminary Biological Activity

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nrn321.pdf (503.59 KB)

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https://academic.oup.com/nass/article/52/1/635/1108725

Permanent Link

https://doi.org/10.1093/nass/nrn321
 http://hdl.handle.net/11603/39607

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UMBC Physics Department
UMBC Chemistry & Biochemistry Department
UMBC Faculty Collection
UMBC GESTAR II
UMBC Joint Center for Earth Systems Technology (JCET)
UMBC Student Collection

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Author/Creator ORCID

https://orcid.org/0000-0002-0154-3459
 https://orcid.org/0000-0001-9491-1654

Date

2008-09-01

Type of Work

journal articles
Text

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Program

Citation of Original Publication

Seley-Radtke, Katherine L., Zhibo Zhang, Orrette R. Wauchope, Sarah C. Zimmermann, Alexander Ivanov, and Brent Korba. “Hetero-Expanded Purine Nucleosides. Design, Synthesis and Preliminary Biological Activity.” Nucleic Acids Symposium Series 52, no. 1 (September 1, 2008): 635–36. https://doi.org/10.1093/nass/nrn321.

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Subjects

UMBC Aerosol, Cloud, Radiation-Observation, and Simulation Group
UMBC Meyerhoff Graduate Fellows Program

Abstract

Several thieno-expanded purine nucleoside analogues were synthesized for use as tools in ongoing investigations into nucleic acid structure and function in our laboratories. The inclusion of the thiophene ring system in the nucleoside endows the purine scaffold with advantages not previously available in other reported expanded purines. The synthesis and preliminary biological studies are reported herein.