Hetero-expanded Purine Nucleosides. Design, Synthesis and Preliminary Biological Activity

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dc.contributor.authorSeley-Radtke, Katherine
dc.contributor.authorZhang, Zhibo
dc.contributor.authorWauchope, Orrette
dc.contributor.authorZimmermann, Sarah Catherine
dc.contributor.authorIvanov, Alexander
dc.contributor.authorKorba, Brent
dc.date.accessioned2025-07-30T19:22:50Z
dc.date.issued2008-09-01
dc.description.abstractSeveral thieno-expanded purine nucleoside analogues were synthesized for use as tools in ongoing investigations into nucleic acid structure and function in our laboratories. The inclusion of the thiophene ring system in the nucleoside endows the purine scaffold with advantages not previously available in other reported expanded purines. The synthesis and preliminary biological studies are reported herein.
dc.description.sponsorshipThe authors thank the National Institutes of Health R01 GM073645 (KSR) for their kind support.
dc.description.urihttps://academic.oup.com/nass/article/52/1/635/1108725
dc.format.extent2 pages
dc.genrejournal articles
dc.identifierdoi:10.13016/m2vfsp-npye
dc.identifier.citationSeley-Radtke, Katherine L., Zhibo Zhang, Orrette R. Wauchope, Sarah C. Zimmermann, Alexander Ivanov, and Brent Korba. “Hetero-Expanded Purine Nucleosides. Design, Synthesis and Preliminary Biological Activity.” Nucleic Acids Symposium Series 52, no. 1 (September 1, 2008): 635–36. https://doi.org/10.1093/nass/nrn321.
dc.identifier.urihttps://doi.org/10.1093/nass/nrn321
dc.identifier.urihttp://hdl.handle.net/11603/39607
dc.language.isoen_US
dc.publisherOxford University Press
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Physics Department
dc.relation.ispartofUMBC Faculty Collection
dc.relation.ispartofUMBC GESTAR II
dc.relation.ispartofUMBC Chemistry & Biochemistry Department
dc.relation.ispartofUMBC Joint Center for Earth Systems Technology (JCET)
dc.relation.ispartofUMBC Student Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.subjectUMBC Aerosol, Cloud, Radiation-Observation, and Simulation Group
dc.subjectUMBC Meyerhoff Graduate Fellows Program
dc.titleHetero-expanded Purine Nucleosides. Design, Synthesis and Preliminary Biological Activity
dc.typeText
dcterms.creatorhttps://orcid.org/0000-0002-0154-3459
dcterms.creatorhttps://orcid.org/0000-0001-9491-1654

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