Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents

Files

molecules2403433v2.pdf (1.01 MB)

Links to Files

https://www.mdpi.com/1420-3049/24/19/3433

Permanent Link

https://doi.org/10.3390/molecules24193433
 http://hdl.handle.net/11603/39568

Collections

UMBC Faculty Collection
UMBC Chemistry & Biochemistry Department

Author/Creator

Author/Creator ORCID

https://orcid.org/0000-0002-0154-3459

Date

2019-09-21

Type of Work

journal articles
Text

Department

Program

Citation of Original Publication

Khandazhinskaya, Anastasia L., Elena S. Matyugina, Pavel N. Solyev, Maggie Wilkinson, Karen W. Buckheit, Robert W. Buckheit, Larisa N. Chernousova, et al. “Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents.” Molecules 24, no. 19 (January 2019): 3433. https://doi.org/10.3390/molecules24193433.

Rights

Attribution 4.0 International

Subjects

nucleosides
leishmanial
mycobacterial
carbocyclic
antiparasitic
tuberculosis

Abstract

Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from our laboratories from two structurally related scaffolds have shown promising activity against both Mycobacterium tuberculosis and several parasitic strains. As a result, a small structure activity relationship study was designed to further probe their activity and potential. Their synthesis and the results of the subsequent biological activity are reported herein.