Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents

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dc.contributor.authorKhandazhinskaya, Anastasia L.
dc.contributor.authorMatyugina, Elena S.
dc.contributor.authorSolyev, Pavel N.
dc.contributor.authorWilkinson, Maggie
dc.contributor.authorBuckheit, Karen W.
dc.contributor.authorBuckheit, Robert W.
dc.contributor.authorChernousova, Larisa N.
dc.contributor.authorSmirnova, Tatiana G.
dc.contributor.authorAndreevskaya, Sofya N.
dc.contributor.authorAlzahrani, Khalid J.
dc.contributor.authorNatto, Manal J.
dc.contributor.authorKochetkov, Sergey N.
dc.contributor.authorde Koning, Harry P.
dc.contributor.authorSeley-Radtke, Katherine
dc.date.accessioned2025-07-30T19:22:35Z
dc.date.issued2019-09-21
dc.description.abstractCarbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from our laboratories from two structurally related scaffolds have shown promising activity against both Mycobacterium tuberculosis and several parasitic strains. As a result, a small structure activity relationship study was designed to further probe their activity and potential. Their synthesis and the results of the subsequent biological activity are reported herein.
dc.description.sponsorshipThis research was funded by Russian Foundation for Basic Research, grant ? 18-29-08010. In addition, KJA was funded through a studentship from Taif University, Taif, Saudi Arabia. MJN was funded by a research fellowship from the government of Saudi Arabia (grant number S8306).
dc.description.urihttps://www.mdpi.com/1420-3049/24/19/3433
dc.format.extent16 pages
dc.genrejournal articles
dc.identifierdoi:10.13016/m2n1vo-xzru
dc.identifier.citationKhandazhinskaya, Anastasia L., Elena S. Matyugina, Pavel N. Solyev, Maggie Wilkinson, Karen W. Buckheit, Robert W. Buckheit, Larisa N. Chernousova, et al. “Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents.” Molecules 24, no. 19 (January 2019): 3433. https://doi.org/10.3390/molecules24193433.
dc.identifier.urihttps://doi.org/10.3390/molecules24193433
dc.identifier.urihttp://hdl.handle.net/11603/39568
dc.language.isoen_US
dc.publisherMDPI
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Faculty Collection
dc.relation.ispartofUMBC Chemistry & Biochemistry Department
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectnucleosides
dc.subjectleishmanial
dc.subjectmycobacterial
dc.subjectcarbocyclic
dc.subjectantiparasitic
dc.subjecttuberculosis
dc.titleInvestigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents
dc.typeText
dcterms.creatorhttps://orcid.org/0000-0002-0154-3459

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