The Migration of Sensory Neurons Following Chemical-Genetic B-Cell Ablation in Danio reno Larvae

Simple item page
dc.contributor.authorRocker, Amanda
dc.contributor.departmentBiological Sciencesen_US
dc.date.accessioned2020-02-24T20:21:16Z
dc.date.available2020-02-24T20:21:16Z
dc.date.issued2018
dc.description.abstractPeripheral nerves act as a vital bridge between the environment and the brain; environmental information is received by sensory neurons and transported, through electrical impulses, along axons to the central nervous system (CNS). The brain processes the information and sends a response back to target organs or muscles through motor axons. When any component of the peripheral nerve is damaged a condition called peripheral neuropathy can develop. This condition often presents in the form of numbness, aching, and burning in the extremities as a result of the nerve damage. One specific cause of peripheral neuropathy is hyperglycemia, an excess of blood glucose which is often associated with diabetes. Damage may be present in both the sensory and motor nerves that make up the peripheral nervous system (PNS), diminishing the ability of those affected to interact with their environment. Preliminary data from the Clark lab suggests that sensory neurons migrate away from their origins at the dorsal root ganglia (DRG). Based upon this work and the knowledge that nerve changes occur in correspondence to hyperglycemia, I hypothesize that the onset of hyperglycemia by pancreatic B-cell ablation results in peripheral neuropathy. Future work will include a small molecule drug screen that may be able to provide insight on the molecular mechanisms underlying hyperglycemia-induced degeneration of the peripheral nerve. Additionally, I plan to study how hyperglycemia presents in the CNS utilizing the same model system.en_US
dc.format.extent18 pagesen_US
dc.genrethesesen_US
dc.identifierdoi:10.13016/m27p88-s5i3
dc.identifier.urihttp://hdl.handle.net/11603/17369
dc.language.isoen_USen_US
dc.relation.isAvailableAtSalisbury Universityen_US
dc.subjectNeuronsen_US
dc.subjectDanio Rio larvaeen_US
dc.titleThe Migration of Sensory Neurons Following Chemical-Genetic B-Cell Ablation in Danio reno Larvaeen_US
dc.typeTexten_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
RockerAmanda_Spring2018.pdf
Size:
2.96 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 2 of 2
No Thumbnail Available
Name:
license.txt
Size:
1.77 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
No Thumbnail Available
Name:
Rocker_SOAR@SU license.pdf
Size:
210.06 KB
Format:
Adobe Portable Document Format
Description:
Download

Collections

SU Honors College Theses