Modeling the Links Between the Chemical, Electrical and Contractile Calcium Dynamics in a Heart Cell
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Type of Work32 pages
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SubjectsCalcium-induced calcium release
Contractile cardiac dynamics
Chemical cardiac dynamics
Electrical cardiac dynamics
High Performance Computing Facilty (HPCF)
Calcium dysregulation is a signi cant cause of fatal cardiac arrythmias, but it is an incompletely understood phenomenon and diffcult to predict. Cardiac calcium levels can be modelled as a system of partial differential equations linking the electrical, calcium, and mechanical dynamics of the heart. Earlier work on this subject established a model linking the chemical and electrical systems, which did not include the contractile or mechanical in uence. We have expanded the most recent extant model to include the mechanical aspect of calcium dynamics in the heart.