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dc.contributor.advisorBeyer, Rachel
dc.contributor.authorAldhubayb, Meshal
dc.date.accessioned2018-12-20T13:39:32Z
dc.date.available2018-12-20T13:39:32Z
dc.date.issued2018-12-19
dc.descriptionIn this study, we investigate the role of LIMP-2 in decreasing the cytotoxicity of the alpha-synuclein in the familial mutations of the alpha-synuclein in Parkinson’s disease models.en_US
dc.description.abstractParkinson’s disease is a slow aggressive neurological disorder characterized by loss of dopamine in substantia nigra which is located in the brain and formats a neuronal cytotoxic protein called alpha- synuclein. Researchers found that genetics plays a significant role in formation of alpha-synuclein aggregation. Studies of families with the history of Parkinson’s disease have identificatied of familial mutations (A30P, E46K, H50Q, G51D, A53T). Researchers have tried to prevent alpha-synuclein aggregation as a way to treat Parkinson’s disease. One possible and promising way to prevent aggregation is overexpression of the lysosomal Integral Membrane Protein type-2 (LIMP-2). In this project, I propose to investigate the role of LIMP-2 in the familial mutation of Parkinson’s diseases. This project uses cellular models for each of the familial mutations for Parkinson’s diseases, inserts of plasmids that contain the LIMP-2 to these cellular models to investigate the effect of the LIMP-2 added on proved aggregation in the familial mutations, and monitor alpha-synuclein aggregation by using Fluorescence Resonance Energy Transfer (FRET) to measure it.en_US
dc.identifierdoi:10.13016/m2wgxg-8t91
dc.identifier.urihttp://hdl.handle.net/11603/12327
dc.language.isoen_USen_US
dc.relation.isAvailableAtHood College
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subjectALPHA-SYNUCLEIN AGGREGATIONen_US
dc.titleCOMPARISON OF ALPHA-SYNUCLEIN AGGREGATION KINETICS IN THE PRESENCE OF LIMP-2 OVEREXPRESSION IN PARKINSONS DISEASE MODEL.en_US
dc.typeCollectionen_US


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Except where otherwise noted, this item's license is described as Attribution-NonCommercial 3.0 United States