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    INFLUENCE OF AERODYNAMIC PARTICLE SIZE ON BOTULINUM NEUROTOXIN POTENCY IN MICE

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    http://hdl.handle.net/11603/20045
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    • Hood College Biomedical and Environmental
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    Author/Creator
    Boydston, Jeremy
    Yeager, John
    Taylor, Jill
    Dabisch, Paul
    Date
    2020-11-12
    Type of Work
    31 pages
    Text
    Thesis
    Department
    Hood College Biology
    Program
    Biomedical and Environmental Science
    Subjects
    Botulinum neurtoxin
    Aerosol
    particle size
    mice
    Abstract
    For many agents the aerodynamic particle size can affect both the virulence and disease course in animal models. Botulinum neurotoxins (BoNTs), which are widely known as potential bioterrorism agents, are toxic via multiple routes of exposure, including small particle inhalation (1-3 μm MMAD). However, the impact of larger particle sizes on the potency of BoNT has not been previously reported. Outbred mice were exposed to BoNT-containing aerosols with differing mass median aerodynamic diameters (MMADs) of 1.1, 4.9, and 7.6 microns. Collecting aerosolized BoNT onto gelatin filters or into liquid impingers resulted in equivalent estimates of aerosol concentration. Nose-only and whole-body inhalation exposure resulted in nearly identical estimates of the median lethal dose (LD50). The LD50 for inhaled BoNT increased approximately 50-fold when the median aerodynamic particle size was increased from 1.1 to 4.9 μm, from 139 (95% CI: 111-185) to 7,324 (95% CI: 4,287-10,891) mouse intraperitoneal median lethal doses (MIPLD50).


    Beneficial-Hodson Library
    Hood College
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    Frederick, MD 21701
    www.hood.edu


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    Beneficial-Hodson Library
    Hood College
    401 Rosemont Avenue
    Frederick, MD 21701
    www.hood.edu


    If you wish to submit a copyright complaint or withdrawal request, please email mdsoar-help@umd.edu.