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    The histone methyltransferases Set5 and Set1 have overlapping functions in gene silencing and telomere maintenance

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    ncbi.nlm.nih.gov/pmc/articles/PMC5330434/
    Permanent Link
    https://doi.org/10.1080%2F15592294.2016.1265712
    http://hdl.handle.net/11603/26701
    Collections
    • UMBC Biological Sciences Department
    • UMBC Faculty Collection
    • UMBC Mathematics and Statistics Department
    • UMBC Student Collection
    Metadata
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    Author/Creator
    Jezek, Meagan
    Gast, Alison
    Choi, Grace
    Kulkarni, Rushmie
    Quijote, Jeremiah
    Graham-Yooll, Andrew
    Park, DoHwan
    Green, Erin
    Author/Creator ORCID
    https://orcid.org/0000-0002-9132-5040
    https://orcid.org/0000-0003-3923-6726
    Date
    2016-12-02
    Type of Work
    12 pages
    Text
    journal articles
    Citation of Original Publication
    Jezek, Meagan et al. “The histone methyltransferases Set5 and Set1 have overlapping functions in gene silencing and telomere maintenance.” Epigenetics 12, no. 2 (2017): 93-104. doi:10.1080/15592294.2016.1265712
    Rights
    This item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
    Subjects
    Gene silencing
    histone acetylation
    histone methylation
    Set1
    Set5
    telomere maintenance
    telomeres
    Abstract
    Genes adjacent to telomeres are subject to transcriptional repression mediated by an integrated set of chromatin modifying and remodeling factors. The telomeres of Saccharomyces cerevisiae have served as a model for dissecting the function of diverse chromatin proteins in gene silencing, and their study has revealed overlapping roles for many chromatin proteins in either promoting or antagonizing gene repression. The H3K4 methyltransferase Set1, which is commonly linked to transcriptional activation, has been implicated in telomere silencing. Set5 is an H4 K5, K8, and K12 methyltransferase that functions with Set1 to promote repression at telomeres. Here, we analyzed the combined role for Set1 and Set5 in gene expression control at native yeast telomeres. Our data reveal that Set1 and Set5 promote a Sir protein-independent mechanism of repression that may primarily rely on regulation of H4K5ac and H4K8ac at telomeric regions. Furthermore, cells lacking both Set1 and Set5 have highly correlated transcriptomes to mutants in telomere maintenance pathways and display defects in telomere stability, linking their roles in silencing to protection of telomeres. Our data therefore provide insight into and clarify potential mechanisms by which Set1 contributes to telomere silencing and shed light on the function of Set5 at telomeres.


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    Albin O. Kuhn Library & Gallery
    University of Maryland, Baltimore County
    1000 Hilltop Circle
    Baltimore, MD 21250
    www.umbc.edu/scholarworks

    Contact information:
    Email: scholarworks-group@umbc.edu
    Phone: 410-455-3021


    If you wish to submit a copyright complaint or withdrawal request, please email mdsoar-help@umd.edu.