UMBC Chemistry & Biochemistry Department
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Recent Submissions
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Identification of the initial nucleocapsid recognition element in the HIV-1 RNA packaging signal
(Proceedings of the National Academy of Sciences, 2020-07-09)Selective packaging of the HIV-1 genome during virus assembly is mediated by interactions between the dimeric 5ʹ-leader of the unspliced viral RNA and the nucleocapsid (NC) domains of a small number of assembling viral Gag ... -
Supporting Deaf Students in Undergraduate Research Experiences: Perspectives of American Sign Language Interpreters
(American Society for Microbiology, 2019-09-29)Deaf undergraduates are eager to engage in research but often feel marginalized due to lack of appropriate accommodations to allow for effective communication within heterogeneous research teams consisting of hearing peers ... -
Chemical and biological sensing using polarity of material
(SPIE, 2020-04-24)Polarity is very important in developing materials with colossal dielectric. To meet the demands for the tunable devices and high dielectric parallel plate capacitors, several perovskites such as CaCu₃Ti₄O₁₂ (CCTO), ... -
Mild Whole Body Hyperthermia Induced Interstitial Fluid Pressure (IFP) Reduction and Enhanced Nanoparticle Delivery to PC3 Tumors: In Vivo Studies and MicroCT Analyses
(The American Society of Mechanical Engineers, 2020-02-28)In vivo experiments on mice were performed to evaluate whether whole body hyperthermia enhances nanoparticle delivery to PC3 tumors. The mice in the experimental group were subjected to whole body hyperthermia by maintaining ... -
Discovery, Design, Synthesis, and Application of Nucleoside/Nucleotides
(MDPI, 2020-03-27) -
Design and fabrication of nano structures for Mid-IR antireflection surface texturing applications
(SPIE, 2020-02-28)Reduction of unwanted light reflection from a surface of a substance is very essential for the improvement of the performance of optical and photonic devices. Anti-reflection (AR) surface textures can be created on the ... -
An Expedient Synthesis of Flexible Nucleosides through Enzymatic Glycosylation of Proximal and Distal Fleximer Bases
(Wiley Online Library, 2020-01-03)The structurally unique “fleximer” nucleosides were originally designed to investigate how flexibility in a nucleobase could potentially affect receptor–ligand recognition and function. Recently they have been shown to ... -
Soluble guanylate cyclase crystal clear: 1st crystal structure of the wild-type human heterodimeric sGC catalytic domains and implications for activity
(Springer, 2013-08-29)Soluble guanylate cyclase (sGC) is the key enzyme in the NO-sGC-cGMP signaling cascade crucial in regulating the cardiovascular system. Low output of this system causes hypertension and acute heart failure, which are the ... -
A Low-Cost and Customizable TEER Meter for the Measurements of Cellular Barrier Integrity
(2019-12-20)A low-cost and translational TEER (trans-endothelial/epithelial electric resistance) meter was designed, fabricated, validated, and applied in this paper. TEER is a critical tool to quantitate the integrity of biological ... -
Elucidation of a non-thermal mechanism for DNA/RNA fragmentation and protein degradation when using Lyse-It
(PLOS, 2019-12-02)Rapid sample preparation is one of the leading bottlenecks to low-cost and efficient sample component detection. To overcome this setback, a technology known as Lyse-It has been developed to rapidly (less than 60 seconds) ... -
Top-down Proteomic Characterization of Truncated Proteoforms
(ACS Publications, 2019-09-10)A top-down proteomic strategy with semi-automated analysis of data sets has proven successful for global identification of truncated proteins without the use of chemical derivatization, enzymatic manipulation, immunoprecipitation ... -
Effects of Lyse-It on endonuclease fragmentation, function and activity
(PLOS, 2019-09-30)Nucleases are enzymes that can degrade genomic DNA and RNA that decrease the accuracy of quantitative measures of those nucleic acids. Here, we study conventional heating, standard microwave irradiation, and Lyse-It, a ... -
Assigning NMR spectra of RNA, peptides and small organic molecules using molecular network visualization software
(Springer Netherlands, 2019-07-19)NMR assignment typically involves analysis of peaks across multiple NMR spectra. Chemical shifts of peaks are measured before being assigned to atoms using a variety of methods. These approaches quickly become complicated ... -
A comparison of Lyse-It to other cellular sample preparation, bacterial lysing, and DNA fragmentation technologies
(PLOS, 2019-07-23)The ability for safe and rapid pathogenic sample transportation and subsequent detection is an increasing challenge throughout the world. Herein, we describe and use bead-beating, vortex, sonication, 903 protein saver ... -
Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors
(PLOS, 2019-07-05)CD47 is an immune checkpoint molecule that downregulates key aspects of both the innate and adaptive anti-tumor immune response via its counter receptor SIRPα, and it is expressed at high levels in a wide variety of tumor ... -
Escherichia Coli FeoC Binds a Redox-Active, Rapidly Oxygen-Sensitive [4Fe-4S] Cluster
(2019-02-07)The acquisition of iron is essential to establishing virulence among most pathogens. Under acidic and/or anaerobic conditions, most bacteria utilize the widely-distributed ferrous iron (Fe²⁺) uptake (Feo) system to import ... -
Distorted perovskites for high voltage dielectric capacitors
(SPIE, 2019-05-13)There are several mechanisms which have been proposed for the existence of colossal dielectric constant in the class of perovskite calcium copper titanate (CaCu₃Ti₄O₁₂ or CCTO) materials. Researches indicate that existence ... -
Design of materials for IR detectors using high Z elements for high energy radiation environment
(SPIE, 2019-05-13)There is a strong need for rad hard and high operating temperature IR detectors for space environment. Heavy metal Selenides (high Z and large density) have been investigated for more than half century for high operating ... -
The Crystal Structure of Klebsiella pneumoniae FeoA Reveals a Site For Protein-Protein Interactions
(2019-01-08)In order to establish infection, pathogenic bacteria must obtain essential nutrients such as iron. Under acidic and/or anaerobic conditions, most bacteria utilize the Feo system in order to acquire ferrous iron (Fe²⁺) from ...
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