UMBC Chemistry & Biochemistry Department
Browse by
Recent Submissions
-
NMR Studies of Retroviral Genome Packaging
(MDPI, 2020-09-30)Nearly all retroviruses selectively package two copies of their unspliced RNA genomes from a cellular milieu that contains a substantial excess of non-viral and spliced viral RNAs. Over the past four decades, combinations ... -
A 3D-Printed, Modular, and Parallelized Microfluidic System with Customizable ECM Integration to Investigate the Roles of Basement Membrane Topography on Endothelial Cells
(2020-09-24)Because dysfunctions of endothelial cells are involved in many pathologies, in vitro endothelial cell models for pathophysiological and pharmaceutical studies have been a valuable research tool. Although numerous ... -
A Modular Toolkit to Fabricate Microfluidic Devices for 3D Cell Culture and Near Real-time Measurements
(figshare, 2020-09-09)Microfluidic technology has tremendously facilitated the development of in vitro cell cultures and studies. Conventionally, microfluidic devices are fabricated with extensive facilities by well-trained researchers, which ... -
Microfibrous extracellular matrix enhances in vitro modeling of the liver hepatocytes by modulating metabolism and integrin expression
(ACM, 2020-01)2 Introduction The liver carries out a number of essential functions, including blood detoxification, protein synthesis, regulation of energy balance, and production of other biochemicals to maintain the whole-body ... -
Effect of Exam Wrappers on Student Achievement in Multiple, Large STEM Courses
Metacognition, the ability to think about and regulate one’s thinking, is an important factor in effective student learning. One intervention to promote student metacognition is the exam wrapper—a reflection students ... -
Design and measurements of n for the multicomponent semiconductor
(SPIE, 2020-08-20)A great deal of research has been performed on refractive index n and extinction coefficient k due to varieties of applications in optical industries. The dispersion equation is described for the photons of varying energies ... -
Identification of the initial nucleocapsid recognition element in the HIV-1 RNA packaging signal
(Proceedings of the National Academy of Sciences, 2020-07-09)Selective packaging of the HIV-1 genome during virus assembly is mediated by interactions between the dimeric 5ʹ-leader of the unspliced viral RNA and the nucleocapsid (NC) domains of a small number of assembling viral Gag ... -
Supporting Deaf Students in Undergraduate Research Experiences: Perspectives of American Sign Language Interpreters
(American Society for Microbiology, 2019-09-29)Deaf undergraduates are eager to engage in research but often feel marginalized due to lack of appropriate accommodations to allow for effective communication within heterogeneous research teams consisting of hearing peers ... -
Chemical and biological sensing using polarity of material
(SPIE, 2020-04-24)Polarity is very important in developing materials with colossal dielectric. To meet the demands for the tunable devices and high dielectric parallel plate capacitors, several perovskites such as CaCu₃Ti₄O₁₂ (CCTO), ... -
Mild Whole Body Hyperthermia Induced Interstitial Fluid Pressure (IFP) Reduction and Enhanced Nanoparticle Delivery to PC3 Tumors: In Vivo Studies and MicroCT Analyses
(The American Society of Mechanical Engineers, 2020-02-28)In vivo experiments on mice were performed to evaluate whether whole body hyperthermia enhances nanoparticle delivery to PC3 tumors. The mice in the experimental group were subjected to whole body hyperthermia by maintaining ... -
Discovery, Design, Synthesis, and Application of Nucleoside/Nucleotides
(MDPI, 2020-03-27) -
Design and fabrication of nano structures for Mid-IR antireflection surface texturing applications
(SPIE, 2020-02-28)Reduction of unwanted light reflection from a surface of a substance is very essential for the improvement of the performance of optical and photonic devices. Anti-reflection (AR) surface textures can be created on the ... -
An Expedient Synthesis of Flexible Nucleosides through Enzymatic Glycosylation of Proximal and Distal Fleximer Bases
(Wiley Online Library, 2020-01-03)The structurally unique “fleximer” nucleosides were originally designed to investigate how flexibility in a nucleobase could potentially affect receptor–ligand recognition and function. Recently they have been shown to ... -
Soluble guanylate cyclase crystal clear: 1st crystal structure of the wild-type human heterodimeric sGC catalytic domains and implications for activity
(Springer, 2013-08-29)Soluble guanylate cyclase (sGC) is the key enzyme in the NO-sGC-cGMP signaling cascade crucial in regulating the cardiovascular system. Low output of this system causes hypertension and acute heart failure, which are the ... -
A Low-Cost and Customizable TEER Meter for the Measurements of Cellular Barrier Integrity
(2019-12-20)A low-cost and translational TEER (trans-endothelial/epithelial electric resistance) meter was designed, fabricated, validated, and applied in this paper. TEER is a critical tool to quantitate the integrity of biological ... -
Elucidation of a non-thermal mechanism for DNA/RNA fragmentation and protein degradation when using Lyse-It
(PLOS, 2019-12-02)Rapid sample preparation is one of the leading bottlenecks to low-cost and efficient sample component detection. To overcome this setback, a technology known as Lyse-It has been developed to rapidly (less than 60 seconds) ... -
Top-down Proteomic Characterization of Truncated Proteoforms
(ACS Publications, 2019-09-10)A top-down proteomic strategy with semi-automated analysis of data sets has proven successful for global identification of truncated proteins without the use of chemical derivatization, enzymatic manipulation, immunoprecipitation ... -
Effects of Lyse-It on endonuclease fragmentation, function and activity
(PLOS, 2019-09-30)Nucleases are enzymes that can degrade genomic DNA and RNA that decrease the accuracy of quantitative measures of those nucleic acids. Here, we study conventional heating, standard microwave irradiation, and Lyse-It, a ...
RSS 1.0