High-Performance Magnetic-core Coils for Targeted Rodent Brain Stimulations
dc.contributor.author | Bagherzadeh, Hedyeh | |
dc.contributor.author | Meng, Qinglei | |
dc.contributor.author | Lu, Hanbing | |
dc.contributor.author | Hong, Elliott | |
dc.contributor.author | Yang, Yihong | |
dc.contributor.author | Choa, Fow-Sen | |
dc.date.accessioned | 2022-03-17T22:23:01Z | |
dc.date.available | 2022-03-17T22:23:01Z | |
dc.date.issued | 2022-03-07 | |
dc.description.abstract | Objective and Impact Statement. There is a need to develop rodent coils capable of targeted brain stimulation for treating neuropsychiatric disorders and understanding brain mechanisms. We describe a novel rodent coil design to improve the focality for targeted stimulations in small rodent brains. Introduction. Transcranial magnetic stimulation (TMS) is becoming increasingly important for treating neuropsychiatric disorders and understanding brain mechanisms. Preclinical studies permit invasive manipulations and are essential for the mechanistic understanding of TMS effects and explorations of therapeutic outcomes in disease models. However, existing TMS tools lack focality for targeted stimulations. Notably, there has been limited fundamental research on developing coils capable of focal stimulation at deep brain regions on small animals like rodents. Methods. In this study, ferromagnetic cores are added to a novel angle-tuned coil design to enhance the coil performance regarding penetration depth and focality. Numerical simulations and experimental electric field measurements were conducted to optimize the coil design. Results. The proposed coil system demonstrated a significantly smaller stimulation spot size and enhanced electric field decay rate in comparison to existing coils. Adding the ferromagnetic core reduces the energy requirements up to 60% for rodent brain stimulation. The simulated results are validated with experimental measurements and demonstration of suprathreshold rodent limb excitation through targeted motor cortex activation. Conclusion. The newly developed coils are suitable tools for focal stimulations of the rodent brain due to their smaller stimulation spot size and improved electric field decay rate. | en_US |
dc.description.sponsorship | The research was supported by the NSF grant ECCS-1631820, NIH grants MH112180, MH108148, MH103222, and a Brain and Behavior Research Foundation grant. It was also partly supported by the Intramural Research Program of the National Institute on Drug Abuse and National Institutes of Health. | en_US |
dc.description.uri | https://spj.sciencemag.org/journals/bmef/aip/9854846/ | en_US |
dc.format.extent | 11 pages | en_US |
dc.genre | journal articles | en_US |
dc.genre | postprints | en_US |
dc.identifier | doi:10.13016/m2i39m-inmr | |
dc.identifier.citation | Bagherzadeh, Hedyeh et al. High-Performance Magnetic-core Coils for Targeted Rodent Brain Stimulations. BME Frontiers. https://spj.sciencemag.org/journals/bmef/aip/9854846/ | en_US |
dc.identifier.uri | https://doi.org/10.34133/2022/9854846 | |
dc.identifier.uri | http://hdl.handle.net/11603/24395 | |
dc.language.iso | en_US | en_US |
dc.publisher | Science Partner Journals | en_US |
dc.relation.isAvailableAt | The University of Maryland, Baltimore County (UMBC) | |
dc.relation.ispartof | UMBC Computer Science and Electrical Engineering Department Collection | |
dc.relation.ispartof | UMBC Student Collection | |
dc.relation.ispartof | UMBC Faculty Collection | |
dc.rights | This item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author. | en_US |
dc.rights | Attribution 4.0 International (CC BY 4.0) | * |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
dc.title | High-Performance Magnetic-core Coils for Targeted Rodent Brain Stimulations | en_US |
dc.type | Text | en_US |
dcterms.creator | https://orcid.org/0000-0002-4646-5212 | en_US |
dcterms.creator | https://orcid.org/0000-0001-9613-6110 | en_US |
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