High-Performance Magnetic-core Coils for Targeted Rodent Brain Stimulations

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dc.contributor.authorBagherzadeh, Hedyeh
dc.contributor.authorMeng, Qinglei
dc.contributor.authorLu, Hanbing
dc.contributor.authorHong, Elliott
dc.contributor.authorYang, Yihong
dc.contributor.authorChoa, Fow-Sen
dc.date.accessioned2022-03-17T22:23:01Z
dc.date.available2022-03-17T22:23:01Z
dc.date.issued2022-03-07
dc.description.abstractObjective and Impact Statement. There is a need to develop rodent coils capable of targeted brain stimulation for treating neuropsychiatric disorders and understanding brain mechanisms. We describe a novel rodent coil design to improve the focality for targeted stimulations in small rodent brains. Introduction. Transcranial magnetic stimulation (TMS) is becoming increasingly important for treating neuropsychiatric disorders and understanding brain mechanisms. Preclinical studies permit invasive manipulations and are essential for the mechanistic understanding of TMS effects and explorations of therapeutic outcomes in disease models. However, existing TMS tools lack focality for targeted stimulations. Notably, there has been limited fundamental research on developing coils capable of focal stimulation at deep brain regions on small animals like rodents. Methods. In this study, ferromagnetic cores are added to a novel angle-tuned coil design to enhance the coil performance regarding penetration depth and focality. Numerical simulations and experimental electric field measurements were conducted to optimize the coil design. Results. The proposed coil system demonstrated a significantly smaller stimulation spot size and enhanced electric field decay rate in comparison to existing coils. Adding the ferromagnetic core reduces the energy requirements up to 60% for rodent brain stimulation. The simulated results are validated with experimental measurements and demonstration of suprathreshold rodent limb excitation through targeted motor cortex activation. Conclusion. The newly developed coils are suitable tools for focal stimulations of the rodent brain due to their smaller stimulation spot size and improved electric field decay rate.en_US
dc.description.sponsorshipThe research was supported by the NSF grant ECCS-1631820, NIH grants MH112180, MH108148, MH103222, and a Brain and Behavior Research Foundation grant. It was also partly supported by the Intramural Research Program of the National Institute on Drug Abuse and National Institutes of Health.en_US
dc.description.urihttps://spj.sciencemag.org/journals/bmef/aip/9854846/en_US
dc.format.extent11 pagesen_US
dc.genrejournal articlesen_US
dc.genrepostprintsen_US
dc.identifierdoi:10.13016/m2i39m-inmr
dc.identifier.citationBagherzadeh, Hedyeh et al. High-Performance Magnetic-core Coils for Targeted Rodent Brain Stimulations. BME Frontiers. https://spj.sciencemag.org/journals/bmef/aip/9854846/en_US
dc.identifier.urihttps://doi.org/10.34133/2022/9854846
dc.identifier.urihttp://hdl.handle.net/11603/24395
dc.language.isoen_USen_US
dc.publisherScience Partner Journalsen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Computer Science and Electrical Engineering Department Collection
dc.relation.ispartofUMBC Student Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.titleHigh-Performance Magnetic-core Coils for Targeted Rodent Brain Stimulationsen_US
dc.typeTexten_US
dcterms.creatorhttps://orcid.org/0000-0002-4646-5212en_US
dcterms.creatorhttps://orcid.org/0000-0001-9613-6110en_US

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