DEVELOPMENT, VALIDATION, AND APPLICATION OF A QUANTITIVE REAL-TIME POLYMERASE CHAIN REACTION ASSAY FOR HUMAN T CELL LEUKEMIA VIRUS DNA
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Hood College Biology
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Biomedical and Environmental Science
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Abstract
A PCR assay to measure HTLV-I/II proviral DNA was developed, validated, and
applied to test a hypothesis relevant to HTLV associated disease pathogenesis. Due to the
potential for functional interaction between HTLV-I/II and HIV regulatory proteins,
HTLV-I/II provirus load might be expected to be higher in HTLV-I/II/HIV co-infected
subjects compared to HTLV-I/II singly infected subjects. However, analysis of HTLV-
I/II provirus load in 37 co-infected and 105 singly infected subjects did not show a
significant difference in HTLV-I/II provirus load (p = 0.35) even when HTLV-I/II
provirus load was adjusted for age and gender.