The Interaction of Calcium and Metabolic Oscillations in Pancreatic β-cells

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dc.contributor.authorAronne, Mary
dc.contributor.authorClapp, Samantha
dc.contributor.authorJung, Soohwan
dc.contributor.authorKramer, Abigail
dc.contributor.authorWang, William
dc.contributor.authorPatwardhan, Janita
dc.contributor.authorPeercy, Bradford E.
dc.contributor.authorSherman, Arthur
dc.date.accessioned2018-09-20T18:51:29Z
dc.date.available2018-09-20T18:51:29Z
dc.date.issued2017
dc.description.abstractDiabetes is a disease characterized by an excessive level of glucose in the bloodstream, which may be a result of improper insulin secretion. Insulin is secreted in a bursting behavior of pancreatic β -cells in islets, which is affected by oscillations of cytosolic calcium concentration. We used the Dual Oscillator Model to explore the role of calcium in calcium oscillation independent and calcium oscillation dependent modes and the synchronization of metabolic oscillations in electrically coupled β -cells. We implemented a synchronization index in order to better measure the synchronization of the β -cells within an islet, and we studied heterogeneous modes of coupled β-cells. We saw that increasing calcium coupling or voltage coupling in heterogeneous cases increases synchronization; however, in certain cases increasing both voltage and calcium coupling causes desynchronization. To better represent an islet, we altered previous code to allow for a greater number of cells to be simulated.en_US
dc.description.sponsorshipterdisciplinary Program in High Performance Computing (hpcreu.umbc.edu) in the Department of Mathematics and Statistics at the University of Maryland, Baltimore County (UMBC) in Summer 2016. This program is funded by the National Science Foundation (NSF), the National Security Agency (NSA), and the Department of Defense (DoD), with additional support from UMBC, the Department of Mathematics and Statistics, the Center for Interdisciplinary Research and Consulting (CIRC), and the UMBC High Performance Computing Facility (HPCF). HPCF is supported by the U.S. National Science Foundation through the MRI program (grant nos. CNS-0821258 and CNS-1228778) and the SCREMS program (grant no. DMS-0821311), with additional substantial support from UMBC. Co-author Mary Aronne was supported, in part, by the UMBC National Security Agency (NSA) Scholars Program through a contract with the NSA. Graduate assistant Janita Patwardan was supported by UMBC.en_US
dc.description.urihttps://ir.library.illinoisstate.edu/cgi/viewcontent.cgi?article=1013&context=sporaen_US
dc.format.extent16 pagesen_US
dc.genreundergraduate journal articleen_US
dc.identifierdoi:10.13016/M2MP4VR6R
dc.identifier.citationAronne, Mary; Clapp, Samantha; Jung, Soohwan; Kramer, Abigail; Wang, William; Patwardhan, Janita; Peercy, Bradford E.; and Sherman, Arthur (2017) "The Interaction of Calcium and Metabolic Oscillations in Pancreatic β-cells," Spora: A Journal of Biomathematics: Vol. 3: Iss.1, DOI: http://doi.org/10.30707/SPORA3.1Aronneen_US
dc.identifier.urihttp://doi.org/10.30707/SPORA3.1Aronne
dc.identifier.urihttp://hdl.handle.net/11603/11333
dc.language.isoen_USen_US
dc.publisherIllinois State Universityen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Mathematics Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.relation.ispartofUMBC Student Collection
dc.rightsThis item may be protected under Title 17 of the U.S. Copyright Law. It is made available by UMBC for non-commercial research and education. For permission to publish or reproduce, please contact the author.
dc.subjectpancreatic β -cellsen_US
dc.subjectisleten_US
dc.subjectcalciumen_US
dc.subjectmetabolic oscillationsen_US
dc.subjectDual Oscillator Modelen_US
dc.subjectUMBC High Performance Computing Facility (HPCF)en_US
dc.titleThe Interaction of Calcium and Metabolic Oscillations in Pancreatic β-cellsen_US
dc.typeTexten_US

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