Facile synthesis of sulfonamide libraries using a solid-polymer-supported HOBt scaffold

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https://www.sciencedirect.com/science/article/pii/S2211715624000547

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https://doi.org/10.1016/j.rechem.2024.101358
 http://hdl.handle.net/11603/31677

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UMBC Chemistry & Biochemistry Department
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UMBC Office of the Dean of the College of Natural and Mathematical Sciences

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https://orcid.org/0000-0003-2635-9460

Date

2024-02-08

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journal articles
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Citation of Original Publication

Guei, Jules Seh Noel, Aristotle Kalivretenos, and William R. LaCourse. “Facile Synthesis of Sulfonamide Libraries Using a Solid-Polymer-Supported HOBt Scaffold.” Results in Chemistry 7 (January 1, 2024): 101358. https://doi.org/10.1016/j.rechem.2024.101358.

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Abstract

Using solid-phase synthetic methods, silica-bound 1-hydroxybenzotriazole (Si-HOBt) was prepared by coupling 3-aminopropyl silica gel with 1-hydroxybenzotriazole-6-carboxylic acid (HOBt-COOH). The Si-HOBt was activated by the reaction of Si-HOBT with 3,4-dihydroxy-9,10-dioxo-anthracenesulfonyl chloride (alizarin red S chloride), resulting in the activated Si-HOBt reagent. The reagent was used to prepare a combination library of sulfonamide derivatives of selected aliphatic and aromatic amines for the development of new therapeutics.