Facile synthesis of sulfonamide libraries using a solid-polymer-supported HOBt scaffold

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dc.contributor.authorGuei, Jules Seh Noel
dc.contributor.authorKalivretenos, Aristotle
dc.contributor.authorLaCourse, William
dc.date.accessioned2024-02-21T14:51:27Z
dc.date.available2024-02-21T14:51:27Z
dc.date.issued2024-02-08
dc.description.abstractUsing solid-phase synthetic methods, silica-bound 1-hydroxybenzotriazole (Si-HOBt) was prepared by coupling 3-aminopropyl silica gel with 1-hydroxybenzotriazole-6-carboxylic acid (HOBt-COOH). The Si-HOBt was activated by the reaction of Si-HOBT with 3,4-dihydroxy-9,10-dioxo-anthracenesulfonyl chloride (alizarin red S chloride), resulting in the activated Si-HOBt reagent. The reagent was used to prepare a combination library of sulfonamide derivatives of selected aliphatic and aromatic amines for the development of new therapeutics.
dc.description.sponsorshipThe authors thank the University of Maryland Baltimore County for financial support for the conduct of the research, Alabama A&M University for financial support for the preparation of the article.
dc.description.urihttps://www.sciencedirect.com/science/article/pii/S2211715624000547
dc.format.extent6 pages
dc.genrejournal articles
dc.identifierdoi:10.13016/m23igi-hdok
dc.identifier.citationGuei, Jules Seh Noel, Aristotle Kalivretenos, and William R. LaCourse. “Facile Synthesis of Sulfonamide Libraries Using a Solid-Polymer-Supported HOBt Scaffold.” Results in Chemistry 7 (January 1, 2024): 101358. https://doi.org/10.1016/j.rechem.2024.101358.
dc.identifier.urihttps://doi.org/10.1016/j.rechem.2024.101358
dc.identifier.urihttp://hdl.handle.net/11603/31677
dc.language.isoen_US
dc.publisherElsevier
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Chemistry & Biochemistry Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.relation.ispartofUMBC Office of the Dean of the College of Natural and Mathematical Sciences
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.rightsCC BY-NC-ND 4.0 DEED Attribution-NonCommercial-NoDerivs 4.0 International en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleFacile synthesis of sulfonamide libraries using a solid-polymer-supported HOBt scaffold
dc.typeText
dcterms.creatorhttps://orcid.org/0000-0003-2635-9460

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