Steroid-Loaded Hemostatic Nanoparticles Combat Lung Injury after Blast Trauma

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https://pubs.acs.org/doi/10.1021/acsmacrolett.5b00061

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https://doi.org/10.1021/acsmacrolett.5b00061
 http://hdl.handle.net/11603/39053

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UMBC Chemical, Biochemical & Environmental Engineering Department
UMBC College of Engineering and Information Technology Dean's Office
UMBC Faculty Collection

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Author/Creator ORCID

https://orcid.org/0000-0002-0644-744X

Date

2015-04-21

Type of Work

journal articles
postprints
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Citation of Original Publication

Hubbard, W. Brad, Margaret M. Lashof-Sullivan, Erin B. Lavik, and Pamela J. VandeVord. "Steroid-Loaded Hemostatic Nanoparticles Combat Lung Injury after Blast Trauma". ACS Macro Letters 4, no. 4 (21 April 2015): 387–91. https://doi.org/10.1021/acsmacrolett.5b00061.

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This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Macro Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsmacrolett.5b00061.

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Abstract

In response to the lack of therapeutics for internal bleeding following a traumatic event, we synthesized hemostatic dexamethasone nanoparticles (hDNP) to help alleviate internal hemorrhaging. hDNP consist of a block copolymer, poly(lactic-co-glycolic acid)-poly(l-lysine)-poly(ethylene glycol) conjugated to a peptide, glycine-arginine-glycine-aspartic acid-serine (GRGDS). These particles were evaluated as treatment for primary blast lung injury in a rodent model. Animals were randomly placed into test and control groups, exposed to blast and given immediate injection. Recovery was assessed using physiological parameters and immunohistochemistry. We found that dexamethasone-loaded hemostatic nanoparticles alleviate physiological deprivation caused by blast injury and reduce lung injury damage.