Steroid-Loaded Hemostatic Nanoparticles Combat Lung Injury after Blast Trauma
| dc.contributor.author | Hubbard, W. Brad | |
| dc.contributor.author | Lashof-Sullivan, Margaret M. | |
| dc.contributor.author | Lavik, Erin | |
| dc.contributor.author | VandeVord, Pamela J. | |
| dc.date.accessioned | 2025-06-17T14:46:34Z | |
| dc.date.available | 2025-06-17T14:46:34Z | |
| dc.date.issued | 2015-04-21 | |
| dc.description.abstract | In response to the lack of therapeutics for internal bleeding following a traumatic event, we synthesized hemostatic dexamethasone nanoparticles (hDNP) to help alleviate internal hemorrhaging. hDNP consist of a block copolymer, poly(lactic-co-glycolic acid)-poly(l-lysine)-poly(ethylene glycol) conjugated to a peptide, glycine-arginine-glycine-aspartic acid-serine (GRGDS). These particles were evaluated as treatment for primary blast lung injury in a rodent model. Animals were randomly placed into test and control groups, exposed to blast and given immediate injection. Recovery was assessed using physiological parameters and immunohistochemistry. We found that dexamethasone-loaded hemostatic nanoparticles alleviate physiological deprivation caused by blast injury and reduce lung injury damage. | |
| dc.description.sponsorship | The authors would like to thank Haiyan Zhang for assistance with histological techniques, as well as Shaylen Hall, Ryan Brady, Carly Norris and Bryce Dunn for assistance with microscopic imaging. Also, the authors would like to acknowledge the funding source: DOD CDMRP Program W81XWH-11-1-0014 and NIH Director’s New Innovator Award number DP20D007338 | |
| dc.description.uri | https://pubs.acs.org/doi/10.1021/acsmacrolett.5b00061 | |
| dc.format.extent | 12 pages | |
| dc.genre | journal articles | |
| dc.genre | postprints | |
| dc.identifier | doi:10.13016/m2qnhr-25s5 | |
| dc.identifier.citation | Hubbard, W. Brad, Margaret M. Lashof-Sullivan, Erin B. Lavik, and Pamela J. VandeVord. "Steroid-Loaded Hemostatic Nanoparticles Combat Lung Injury after Blast Trauma". ACS Macro Letters 4, no. 4 (21 April 2015): 387–91. https://doi.org/10.1021/acsmacrolett.5b00061. | |
| dc.identifier.uri | https://doi.org/10.1021/acsmacrolett.5b00061 | |
| dc.identifier.uri | http://hdl.handle.net/11603/39053 | |
| dc.language.iso | en_US | |
| dc.publisher | ACS | |
| dc.relation.isAvailableAt | The University of Maryland, Baltimore County (UMBC) | |
| dc.relation.ispartof | UMBC Chemical, Biochemical & Environmental Engineering Department | |
| dc.relation.ispartof | UMBC Faculty Collection | |
| dc.relation.ispartof | UMBC College of Engineering and Information Technology Dean's Office | |
| dc.rights | This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Macro Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsmacrolett.5b00061. | |
| dc.title | Steroid-Loaded Hemostatic Nanoparticles Combat Lung Injury after Blast Trauma | |
| dc.type | Text | |
| dcterms.creator | https://orcid.org/0000-0002-0644-744X |