Urinary Biomarkers and Joint Cognition-Gait Trajectories: Findings from the Health, Aging, and Body Composition (ABC) Study: SA-PO1113

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https://journals.lww.com/jasn/fulltext/2025/10001/urinary_biomarkers_and_joint_cognition_gait.3764.aspx

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http://hdl.handle.net/11603/40811

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UMBC Sociology, Anthropology, and Public Health Department

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https://orcid.org/0000-0001-5990-108X

Date

2025-10-01

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journal articles
posters
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Citation of Original Publication

Shrestha, Aman, Michelle Shardell, Chixiang Chen, et al. “Urinary Biomarkers and Joint Cognition-Gait Trajectories: Findings from the Health, Aging, and Body Composition (ABC) Study: SA-PO1113.” Journal of the American Society of Nephrology 36, no. 10S (2025): 10.1681/ASN.2025ggvad3kf. https://doi.org/10.1681/ASN.2025ggvad3kf.

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Abstract

Background: Emerging urinary biomarkers can unlock new links between kidney tubular injury and cognitive-physical function. Methods: Using the Health ABC Study, we examined baseline urinary biomarkers—uromodulin, alpha-1 microglobulin (α1M), amino-terminal propeptide of type-III procollagen (PIIINP), neutrophil gelatinase-associated lipocalin (NGAL), interlukin-18 (IL-18), and kidney injury molecule-1 (KIM-1)—and joint cognition-gait trajectories among baseline high-function older adults. IL-18 and KIM-1 were measured in n=1902 participants; uromodulin, α1M, PIIINP and NGAL were measured in a random subcohort (n=502). Group-based trajectory analysis of 20m usual gait speed and modified Mini-Mental State up to year 10 revealed three groups: high cognitive-physical function (Group 1), stable cognition/declining gait (Group 2), and rapid joint decline (Group 3). Results: After adjusting for covariates in separate models (Model-1A), higher α1M (p=0.043) and KIM-1 (p=0.005) concentrations were related to worse trajectories (Table). Further adjustment for estimated glomerular filtration rate (eGFR), urine albumin-to-creatinine ratio (UACR) and c-reactive protein (CRP) (Model-1B) attenuated estimates; KIM-1 was not quite significant (p=0.059). In a fully adjusted model of all urinary markers (Model-2), only KIM-1 was significant (p=0.012), but the set of urinary biomarkers was jointly significant (p=0.022). Conclusion: KIM-1 was robustly related to cognitive-gait decline, and may link kidney tubular injury with aging-related functional outcomes.