Urinary Biomarkers and Joint Cognition-Gait Trajectories: Findings from the Health, Aging, and Body Composition (ABC) Study: SA-PO1113

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dc.contributor.authorShrestha, Aman
dc.contributor.authorShardell, Michelle
dc.contributor.authorChen, Chixiang
dc.contributor.authorSeliger, Stephen L.
dc.contributor.authorGinsberg, Charles
dc.contributor.authorMiller, Lindsay M.
dc.contributor.authorCawthon, Peggy M.
dc.date.accessioned2025-11-21T00:29:53Z
dc.date.issued2025-10-01
dc.description.abstractBackground: Emerging urinary biomarkers can unlock new links between kidney tubular injury and cognitive-physical function. Methods: Using the Health ABC Study, we examined baseline urinary biomarkers—uromodulin, alpha-1 microglobulin (α1M), amino-terminal propeptide of type-III procollagen (PIIINP), neutrophil gelatinase-associated lipocalin (NGAL), interlukin-18 (IL-18), and kidney injury molecule-1 (KIM-1)—and joint cognition-gait trajectories among baseline high-function older adults. IL-18 and KIM-1 were measured in n=1902 participants; uromodulin, α1M, PIIINP and NGAL were measured in a random subcohort (n=502). Group-based trajectory analysis of 20m usual gait speed and modified Mini-Mental State up to year 10 revealed three groups: high cognitive-physical function (Group 1), stable cognition/declining gait (Group 2), and rapid joint decline (Group 3). Results: After adjusting for covariates in separate models (Model-1A), higher α1M (p=0.043) and KIM-1 (p=0.005) concentrations were related to worse trajectories (Table). Further adjustment for estimated glomerular filtration rate (eGFR), urine albumin-to-creatinine ratio (UACR) and c-reactive protein (CRP) (Model-1B) attenuated estimates; KIM-1 was not quite significant (p=0.059). In a fully adjusted model of all urinary markers (Model-2), only KIM-1 was significant (p=0.012), but the set of urinary biomarkers was jointly significant (p=0.022). Conclusion: KIM-1 was robustly related to cognitive-gait decline, and may link kidney tubular injury with aging-related functional outcomes.
dc.description.sponsorshipOther NIH Support - National Institute of Aging, National Institute of Neurological Disorders and Stroke
dc.description.urihttps://journals.lww.com/jasn/fulltext/2025/10001/urinary_biomarkers_and_joint_cognition_gait.3764.aspx
dc.format.extent3 pages
dc.genrejournal articles
dc.genreposters
dc.identifierdoi:10.13016/m2iohe-evmk
dc.identifier.citationShrestha, Aman, Michelle Shardell, Chixiang Chen, et al. “Urinary Biomarkers and Joint Cognition-Gait Trajectories: Findings from the Health, Aging, and Body Composition (ABC) Study: SA-PO1113.” Journal of the American Society of Nephrology 36, no. 10S (2025): 10.1681/ASN.2025ggvad3kf. https://doi.org/10.1681/ASN.2025ggvad3kf.
dc.identifier.urihttp://hdl.handle.net/11603/40811
dc.language.isoen
dc.publisherWolters Kluwer Health
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Student Collection
dc.relation.ispartofUMBC Sociology, Anthropology, and Public Health
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.titleUrinary Biomarkers and Joint Cognition-Gait Trajectories: Findings from the Health, Aging, and Body Composition (ABC) Study: SA-PO1113
dc.typeText
dcterms.creatorhttps://orcid.org/0000-0001-5990-108X

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