Using Polymer Chemistry to Modulate the Delivery of Neurotrophic Factors from Degradable Microspheres: Delivery of BDNF

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https://link.springer.com/article/10.1007/s11095-009-0009-x

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https://doi.org/10.1007/s11095-009-0009-x
 http://hdl.handle.net/11603/39068

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UMBC Chemical, Biochemical & Environmental Engineering Department
UMBC College of Engineering and Information Technology Dean's Office

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https://orcid.org/0000-0002-0644-744X

Date

2010-01-01

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journal articles
postprints
Text

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Citation of Original Publication

Bertram, James P., Millicent F. Rauch, Kaliq Chang, and Erin B. Lavik. “Using Polymer Chemistry to Modulate the Delivery of Neurotrophic Factors from Degradable Microspheres: Delivery of BDNF.” Pharmaceutical Research 27, no. 1 (January 1, 2010): 82–91. https://doi.org/10.1007/s11095-009-0009-x.

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This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s11095-009-0009-x.

Subjects

BDNF
microparticle
PLGA
PEG
Polymers
microsphere

Abstract

Brain-derived neurotrophic factor (BDNF) plays an important role in neuroprotection and repair, but long-term delivery from polymer systems has been challenging. We investigated the role the chemistry of the polymer played in loading and delivery of BDNF via microspheres, which are suitable for minimally invasive administration.