Using Polymer Chemistry to Modulate the Delivery of Neurotrophic Factors from Degradable Microspheres: Delivery of BDNF

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dc.contributor.authorBertram, James P.
dc.contributor.authorRauch, Millicent F.
dc.contributor.authorChang, Kaliq
dc.contributor.authorLavik, Erin
dc.date.accessioned2025-06-17T14:46:41Z
dc.date.available2025-06-17T14:46:41Z
dc.date.issued2010-01-01
dc.description.abstractBrain-derived neurotrophic factor (BDNF) plays an important role in neuroprotection and repair, but long-term delivery from polymer systems has been challenging. We investigated the role the chemistry of the polymer played in loading and delivery of BDNF via microspheres, which are suitable for minimally invasive administration.
dc.description.sponsorshipThis work was funded through the generous support of Richard and Gail Siegal and the Coulter Foundation
dc.description.urihttps://link.springer.com/article/10.1007/s11095-009-0009-x
dc.format.extent34 pages
dc.genrejournal articles
dc.genrepostprints
dc.identifierdoi:10.13016/m26omi-nwmk
dc.identifier.citationBertram, James P., Millicent F. Rauch, Kaliq Chang, and Erin B. Lavik. “Using Polymer Chemistry to Modulate the Delivery of Neurotrophic Factors from Degradable Microspheres: Delivery of BDNF.” Pharmaceutical Research 27, no. 1 (January 1, 2010): 82–91. https://doi.org/10.1007/s11095-009-0009-x.
dc.identifier.urihttps://doi.org/10.1007/s11095-009-0009-x
dc.identifier.urihttp://hdl.handle.net/11603/39068
dc.language.isoen_US
dc.publisherSpringer
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Chemical, Biochemical & Environmental Engineering Department
dc.relation.ispartofUMBC College of Engineering and Information Technology Dean's Office
dc.rightsThis version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s11095-009-0009-x.
dc.subjectBDNF
dc.subjectmicroparticle
dc.subjectPLGA
dc.subjectPEG
dc.subjectPolymers
dc.subjectmicrosphere
dc.titleUsing Polymer Chemistry to Modulate the Delivery of Neurotrophic Factors from Degradable Microspheres: Delivery of BDNF
dc.typeText
dcterms.creatorhttps://orcid.org/0000-0002-0644-744X

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