Network Analytics towards Drug Repositioning using Phosphorylated Proteins.

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dc.contributor.advisorGangopadhyay, Aryya
dc.contributor.authorODEBODE, IYANUOLUWA EMMANUEL
dc.contributor.departmentInformation Systems
dc.contributor.programInformation Systems
dc.date.accessioned2021-01-29T18:12:26Z
dc.date.available2021-01-29T18:12:26Z
dc.date.issued2019-01-01
dc.description.abstractDrug Repositioning is an approach to discovering a new use of old drugs. However, current successes in drug repositioning have primarily been a result of serendipity or clinical observations, such as the observed use of sildenafil citrate (Viagra) mostly for the treatment of erectile dysfunction, but now repositioned for the treatment of pulmonary arterial hypertension, leprosy, and erectile dysfunction induced depression. Besides, thalidomide used for inducing sedation is now known to be potent for the treatment of multiple myeloma To transform this process systematically, many computational approaches have emerged with recent advances in computational technology, to automatically identify possible drug repositioning candidates by accessing an overwhelming volume of biomedical data. In this study, we described an effort made on computational drug repositioning by applying sequence encoding, sequence analysis, and network analytics against the phosphorylated proteins. We propose a novel framework towards computational drug repositioning with multiple components, 1) sequence analysis and sequence prioritization 2) biological interaction network construction by integrating heterogeneous interactions among gene, disease, protein, snp, etc.; 2) phosphorylated network creation 3) high-influence node detection/prioritization by applying network analysis and perturbation; 4) multimodal network creation and clustering 5) drug candidate identification and evaluation by using sequence analysis and cheminformatic techniques. We used the pim substrates, diabetes and rhabdomyosarcoma as a case study.
dc.formatapplication:pdf
dc.genredissertations
dc.identifierdoi:10.13016/m2gong-xxhu
dc.identifier.other12008
dc.identifier.urihttp://hdl.handle.net/11603/20705
dc.languageen
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Information Systems Department Collection
dc.relation.ispartofUMBC Theses and Dissertations Collection
dc.relation.ispartofUMBC Graduate School Collection
dc.relation.ispartofUMBC Student Collection
dc.sourceOriginal File Name: ODEBODE_umbc_0434D_12008.pdf
dc.subjectDrug Repositioning
dc.subjectPhosphorylated Proteins
dc.titleNetwork Analytics towards Drug Repositioning using Phosphorylated Proteins.
dc.typeText
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